The incidence of congenital hemophilia A is about 1 in 5000 boys/men, whereas the incidence of congenital hemophilia B is about 1 in 30,000 boys/men.  Each year around 400 babies are born with hemophilia in the US.  The prevalence of congenital hemophilia in the US is estimated as 18,000 boys/men, most of which are classified as severe.  Congenital hemophilia affects all ethnic groups and has a worldwide distribution.  Its inheritance pattern is X-linked.  Therefore, boys/men are exclusively affected, although rare cases of girls/women with hemophilia are described, such as those seen due to lyonization (random inactivation of the normal X chromosome), homozygosity, mosaicism, or Turner syndrome.
Acquired hemophilia affects around 1 to 3 people per million of the population. Both sexes are equally affected. As with the conventional inherited form, the condition appears in all ethnic groups and has a worldwide prevalence.
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