A 46-year-old woman presents with fatigue and is found to have iron deficiency with anemia. She has experienced intermittent episodes of mild diarrhea for many years, previously diagnosed as irritable bowel syndrome and lactose intolerance. She has no current significant gastrointestinal symptoms. Examination reveals 2 oral aphthous ulcers and pallor. Abdominal examination is normal and results of fecal testing for occult blood are negative.
Atypical presentations include an asymptomatic patient, elevated liver enzymes, vitamin D deficiency, osteopenia or osteoporosis, constipation, aphthous stomatitis, nausea or vomiting, heartburn or gastroesophageal reflux disease, hyposplenia or asplenia, myalgias, arthralgias, peripheral neuropathy, alopecia, headaches, infertility, and adverse pregnancy outcomes.
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