Caused by acute inflammation of the renal interstitium, most likely mediated by a hypersensitivity reaction.
Usually triggered by an offending medication, of which >100 are known. Also occurs in chronic inflammatory disease.
Presents with acute renal failure and the "hypersensitivity triad" of rash, fever, and eosinophilia. Nephrotic syndrome may also be present in cases triggered by nonsteroidal anti-inflammatory drugs (NSAIDs).
Usually resolves once the offending medication is discontinued.
Treatment is largely supportive, with management of fluid electrolyte balance and fluid retention. Corticosteroid therapy may be given to increase the rate and extent of renal functional recovery.
Prognosis is good, although most patients have some residual renal impairment.
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