Chronic progressive seronegative inflammatory arthritis occurring in patients with underlying psoriasis.
Polyarticular psoriatic arthritis distinguished from rheumatoid arthritis by presence of dactylitis and absence of anti-cyclic citrullinated peptide antibodies.
Nonsteroidal anti-inflammatory drugs (NSAIDs) usually sufficient to treat limited disease.
Patients with progressive peripheral arthritis (polyarthritis, joint erosions) or oligoarthritis refractory to NSAIDs and/or intra-articular corticosteroids require disease-modifying antirheumatic disease therapy (e.g., methotrexate) early in disease course.
Tumor necrosis factor (TNF)-alpha inhibitors may be considered as second-line therapy for most disease manifestations.
From the collection of Dr Tsu-Yi Chuang; used with permission