A common sexually transmitted infection. Approximately 10 million to 12 million new infections worldwide each year.
Caused by the spirochete bacterium Treponema pallidum, subspecies pallidum.
Clinical presentation is often asymptomatic, but can manifest in a number of ways.
Diagnosis is usually straightforward after clinical exam and serologic tests. Treatment is with penicillin.
Untreated syphilis facilitates HIV transmission and causes considerable morbidity, such as cardiovascular and neurologic disease.
Syphilis in pregnancy is a major cause of miscarriage, stillbirth, and perinatal morbidity and mortality in some parts of the world.
A primary syphilitic chancre of the lip