Last Updated: 2014-01-16
Syndrome of mild unconjugated hyperbilirubinemia, by definition <6 mg/dL.
Common syndrome affecting 3% to 7% of the general population.
Decreased bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UDPGT) activity leads to decreased conjugation of unconjugated bilirubin.
Presentation usually asymptomatic or mild icterus (jaundice) seen during times of fasting or physiological stress.
No treatment is needed since there is no liver injury or progression to end stage liver disease.
Although prognosis continues to be excellent, there is evidence that some patients with Gilbert syndrome may have abnormalities in the metabolism of selective protease inhibitor drugs and monoclonal antibodies used in the treatment of rheumatological disease.
Patient on right is jaundiced, similar to jaundice caused by severe Gilbert syndrome
From the personal collection of Dr John L. Gollan
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