Clinically presents as a pearly white papulo-nodule or firm plaque.
Patient usually has prominent solar damage or a history of considerable UV exposure.
Biopsy with histopathologic evaluation is essential; findings are of dermal masses of varying sizes and shapes composed of basophilic cells with large oval rather uniform nuclei and scant cytoplasm. These masses exhibit a peripheral cell layer demonstrating a palisading pattern of nuclei.
Treatment varies, remembering that the diagnosis of a cancer is histologic.
Complications are unusual if this cancer is treated properly.
Nodular basal cell carcinoma on the cheek, on background of diffuse solar damage with marked solar elastosis
From the personal collection of Robert A. Schwartz, MD, MPH, FACP, FAAD
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