Infection of blood or other normally sterile site with Candida species; usually in association with fever, hypotension, and/or leukocytosis.
Major risk factors are use of central venous catheters, exposure to broad-spectrum antibiotics, and neutropenia.
Blood cultures are only 70% to 80% sensitive in diagnosis.
Therapy should be started within 24 hours of diagnosis to improve outcome. Fluconazole or echinocandins are first-line choices.
Ophthalmologic exam is required in all patients with candidemia.
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