Black Box Warnings .
Serious Skin Rxns
D/C telaprevir, peginterferon alfa, and ribavirin combo tx if serious skin rxns incl. rash w/ systemic sx or progressive severe rash occur; refer pts for urgent medical care and consider D/C other drugs assoc. w/ serious skin rxns; fatal and non-fatal rxns reported w/ combo tx incl. Stevens Johnson Syndrome, drug rxn w/ eosinophilia and systemic sx (DRESS), and toxic epidermal necrolysis; fatal cases reported in pts who continued combo tx after identification of serious progressive rash w/ systemic sx