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methoxsalen
generic
Black Box Warnings .
Appropriate Use
use only by physicians experienced in psoriasis diagnosis/tx w/ special training in photochemotherapy; use w/ radiation tx under constant physician supervision; restrict psoriasis use to severe recalcitrant disabling dz not adequately responsive to other tx; use dosimetry specifically recommended for product; determine minimum phototoxic dose and phototoxic peak time prior to starting photochemotherapy
Ocular/Skin Damage, Skin Cancer
fully inform pt of risks of ocular damage, skin damage/aging, and skin CA incl. melanoma
Non-Interchangeable Forms
methoxsalen soft gelatin and hard gelatin caps not bioequivalent; methoxsalen soft gelatin caps exhibit significantly greater bioavailability and earlier photosensitization onset time than other forms; do not interchange products w/o retitrating pt
Adult Dosing .
Dosage forms: CAP (soft gelatin): 10 mg
Special Note
- [formulation clarification]
- Info: do not interchange methoxsalen soft gelatin and hard gelatin caps without retitrating pt
- [dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for dosing incl. toxicity-related dose adjustments
psoriasis, severe recalcitrant disabling
- [<30 kg]
- Dose: 10-20 mg PO per session; Start: 10 mg PO per session, may incr. dose by 10 mg/session if inadequate response after 15 sessions; Max: 20 mg/dose; 1 dose/48h; Info: give w/ milk or food 1.5-2h prior to phototherapy
- [30-50 kg]
- Dose: 20-30 mg PO per session; Start: 20 mg PO per session, may incr. dose by 10 mg/session if inadequate response after 15 sessions; Max: 30 mg/dose; 1 dose/48h; Info: give w/ milk or food 1.5-2h prior to phototherapy
- [51-65 kg]
- Dose: 30-40 mg PO per session; Start: 30 mg PO per session, may incr. dose by 10 mg/session if inadequate response after 15 sessions; Max: 40 mg/dose; 1 dose/48h; Info: give w/ milk or food 1.5-2h prior to phototherapy
- [66-80 kg]
- Dose: 40-50 mg PO per session; Start: 40 mg PO per session, may incr. dose by 10 mg/session if inadequate response after 15 sessions; Max: 50 mg/dose; 1 dose/48h; Info: give w/ milk or food 1.5-2h prior to phototherapy
- [81-90 kg]
- Dose: 50-60 mg PO per session; Start: 50 mg PO per session, may incr. dose by 10 mg/session if inadequate response after 15 sessions; Max: 60 mg/dose; 1 dose/48h; Info: give w/ milk or food 1.5-2h prior to phototherapy
- [91-115 kg]
- Dose: 60-70 mg PO per session; Start: 60 mg PO per session, may incr. dose by 10 mg/session if inadequate response after 15 sessions; Max: 70 mg/dose; 1 dose/48h; Info: give w/ milk or food 1.5-2h prior to phototherapy
- [>115 kg]
- Dose: 70-80 mg PO per session; Start: 70 mg PO per session, may incr. dose by 10 mg/session if inadequate response after 15 sessions; Max: 80 mg/dose; 1 dose/48h; Info: give w/ milk or food 1.5-2h prior to phototherapy
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.