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Adult Dosing .
Dosage forms: 120,240 DR
multiple sclerosis, relapsing forms
- [240 mg PO bid]
- Start: 120 mg PO bid x7 days, then 240 mg PO bid; Info: may temporarily decr. dose to 120 mg PO bid if not tolerated, then resume usual dose of 240 mg PO bid w/in 4wk or consider D/C if usual dose still not tolerated; see pkg insert for tx considerations based on lymphopenia; consider giving w/ food to reduce flushing; do not crush/chew/open
- [not defined]
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
- hypersens. to drug/class/compon.
Drug Interactions .
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
- flushing, severe
- abdominal pain
- AST incr.
Lactation: Safety Unknown
CBC w/ diff at baseline, 6mo after tx start, then q6-12mo and as clinically indicated
Metabolism: GI tract, plasma, and tissue; CYP450: none; Info: active metabolite
Excretion: lungs 60%, urine 16%, feces 1%; Half-life: 1h
Subclass: Multiple Sclerosis
Mechanism of Action
exact mechanism in multiple sclerosis unknown; activates nuclear factor-like 2 (Nrf2) pathway, resulting in cellular response to oxidative stress
Manufacturer: Biogen Idec
Approximate Retail Price
This information is currently not available for this drug.
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