# Flucelvax

## influenza A and B vaccine, inactivated trivalent

## Entire Monograph

## Adult Dosing .

**Dosage forms:** IM

### Vaccine Adverse Event Reporting

- [1-800-822-7967 or http://vaers.hhs.gov]

### immunization

- [0.5 mL IM x1 annually]
- Info: refer to Vaccinations: Routine Adult Immunization Schedule table and www.cdc.gov/flu for target populations and prioritization

### renal dosing

- [not defined]

### hepatic dosing

- [not defined]

## Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.

## Contraindications/Cautions .

- hypersens. to drug/class/compon.
- caution if hypersens. to latex
- caution if Guillain-Barre syndrome w/in 6wk of prior influenza vaccine
- caution if immunocompromised
- caution if acute illness, mod-severe

## Drug Interactions .

### Overview

**influenza vaccine**

- vaccine or toxoid

## Monitor/Modify Tx

- aminophylline
- fingolimod
- fosphenytoin
- phenytoin
- rituximab
- theophylline
- warfarin

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**aminophylline**

## Monitor/Modify Tx

influenza vaccine + aminophylline

**caution advised, monitor theophylline levels**: combo may incr. theophylline levels, risk of adverse effects (mechanism unknown, hepatic metab. possibly inhibited)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**fingolimod**

## Monitor/Modify Tx

influenza vaccine + fingolimod

**caution advised during fingolimod tx and x2mo after D/C, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**fosphenytoin**

## Monitor/Modify Tx

influenza vaccine + fosphenytoin

**caution advised, monitor phenytoin levels**: combo may incr. phenytoin levels, risk of toxicity (mechanism unknown, hepatic metab. possibly inhibited)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**phenytoin**

## Monitor/Modify Tx

influenza vaccine + phenytoin

**caution advised, monitor phenytoin levels**: combo may incr. phenytoin levels, risk of toxicity (mechanism unknown, hepatic metab. possibly inhibited)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**rituximab**

## Monitor/Modify Tx

influenza vaccine + rituximab

**vaccinate >4wk before rituximab course**: combo may result in inadequate immunologic response to vaccine or toxoid (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**theophylline**

## Monitor/Modify Tx

influenza vaccine + theophylline

**caution advised, monitor theophylline levels**: combo may incr. theophylline levels, risk of adverse effects (mechanism unknown, hepatic metab. possibly inhibited)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**warfarin**

## Monitor/Modify Tx

influenza vaccine + warfarin

**caution advised w/ IM injections when anticoagulated, monitor INR**: combo may incr. INR, risk of bleeding (mechanism unknown, hepatic metab. possibly inhibited)

## Caution Advised

- abatacept
- adalimumab
- aldesleukin
- alefacept
- alemtuzumab
- altretamine
- anakinra
- antithymocyte globulin
- azacitidine
- azathioprine
- basiliximab
- belatacept
- belimumab
- bendamustine
- betamethasone
- bleomycin
- busulfan
- cabazitaxel
- canakinumab
- capecitabine
- carboplatin
- carmustine
- certolizumab pegol
- chlorambucil
- cisplatin
- cladribine
- cortisone
- cyclophosphamide
- cyclosporine
- cytarabine
- dacarbazine
- dactinomycin
- dasatinib
- daunorubicin
- decitabine
- dexamethasone
- docetaxel
- doxorubicin
- efalizumab
- epirubicin
- eribulin
- etanercept
- etoposide
- everolimus
- floxuridine
- fludarabine
- fluorouracil
- gemcitabine
- gemtuzumab ozogamicin
- golimumab
- hydrocortisone
- hydroxyurea
- ibritumomab tiuxetan
- ibrutinib
- idarubicin
- ifosfamide
- infliximab
- irinotecan
- ixabepilone
- leflunomide
- lenalidomide
- lomustine
- lymphocyte immune globulin, antithymocyte globulin
- mechlorethamine
- melphalan
- mercaptopurine
- methotrexate
- methylprednisolone
- mitomycin
- mitoxantrone
- muromonab-CD3
- mycophenolate mofetil
- mycophenolic acid
- natalizumab
- nelarabine
- obinutuzumab
- ofatumumab
- omacetaxine mepesuccinate
- oxaliplatin
- paclitaxel
- pemetrexed
- pentostatin
- pralatrexate
- prednisolone
- prednisone
- ruxolitinib
- siltuximab
- sirolimus
- tacrolimus
- temozolomide
- temsirolimus
- teniposide
- teriflunomide
- thioguanine
- thiotepa
- tocilizumab
- tofacitinib
- topotecan
- tositumomab
- triamcinolone
- ustekinumab
- vedolizumab
- vinblastine
- vincristine
- vinorelbine

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**abatacept**

## Caution Advised

influenza vaccine + abatacept

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**adalimumab**

## Caution Advised

influenza vaccine + adalimumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**aldesleukin**

## Caution Advised

influenza vaccine + aldesleukin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**alefacept**

## Caution Advised

influenza vaccine + alefacept

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**alemtuzumab**

## Caution Advised

influenza vaccine + alemtuzumab

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**altretamine**

## Caution Advised

influenza vaccine + altretamine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**anakinra**

## Caution Advised

influenza vaccine + anakinra

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (interference w/ immune response mechanisms to new antigens)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**antithymocyte globulin**

## Caution Advised

influenza vaccine + antithymocyte globulin

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**azacitidine**

## Caution Advised

influenza vaccine + azacitidine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**azathioprine**

## Caution Advised

influenza vaccine + azathioprine

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**basiliximab**

## Caution Advised

influenza vaccine + basiliximab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**belatacept**

## Caution Advised

influenza vaccine + belatacept

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**belimumab**

## Caution Advised

influenza vaccine + belimumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**bendamustine**

## Caution Advised

influenza vaccine + bendamustine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**betamethasone**

## Caution Advised

influenza vaccine + betamethasone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**bleomycin**

## Caution Advised

influenza vaccine + bleomycin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine or toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**busulfan**

## Caution Advised

influenza vaccine + busulfan

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cabazitaxel**

## Caution Advised

influenza vaccine + cabazitaxel

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**canakinumab**

## Caution Advised

influenza vaccine + canakinumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**capecitabine**

## Caution Advised

influenza vaccine + capecitabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**carboplatin**

## Caution Advised

influenza vaccine + carboplatin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**carmustine**

## Caution Advised

influenza vaccine + carmustine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**certolizumab pegol**

## Caution Advised

influenza vaccine + certolizumab pegol

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**chlorambucil**

## Caution Advised

influenza vaccine + chlorambucil

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cisplatin**

## Caution Advised

influenza vaccine + cisplatin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cladribine**

## Caution Advised

influenza vaccine + cladribine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cortisone**

## Caution Advised

influenza vaccine + cortisone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cyclophosphamide**

## Caution Advised

influenza vaccine + cyclophosphamide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cyclosporine**

## Caution Advised

influenza vaccine + cyclosporine

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cytarabine**

## Caution Advised

influenza vaccine + cytarabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**dacarbazine**

## Caution Advised

influenza vaccine + dacarbazine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**dactinomycin**

## Caution Advised

influenza vaccine + dactinomycin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**dasatinib**

## Caution Advised

influenza vaccine + dasatinib

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**daunorubicin**

## Caution Advised

influenza vaccine + daunorubicin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**decitabine**

## Caution Advised

influenza vaccine + decitabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**dexamethasone**

## Caution Advised

influenza vaccine + dexamethasone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**docetaxel**

## Caution Advised

influenza vaccine + docetaxel

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**doxorubicin**

## Caution Advised

influenza vaccine + doxorubicin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**efalizumab**

## Caution Advised

influenza vaccine + efalizumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**epirubicin**

## Caution Advised

influenza vaccine + epirubicin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**eribulin**

## Caution Advised

influenza vaccine + eribulin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**etanercept**

## Caution Advised

influenza vaccine + etanercept

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**etoposide**

## Caution Advised

influenza vaccine + etoposide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**everolimus**

## Caution Advised

influenza vaccine + everolimus

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**floxuridine**

## Caution Advised

influenza vaccine + floxuridine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**fludarabine**

## Caution Advised

influenza vaccine + fludarabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**fluorouracil**

## Caution Advised

influenza vaccine + fluorouracil

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**gemcitabine**

## Caution Advised

influenza vaccine + gemcitabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**gemtuzumab ozogamicin**

## Caution Advised

influenza vaccine + gemtuzumab ozogamicin

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**golimumab**

## Caution Advised

influenza vaccine + golimumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**hydrocortisone**

## Caution Advised

influenza vaccine + hydrocortisone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**hydroxyurea**

## Caution Advised

influenza vaccine + hydroxyurea

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ibritumomab tiuxetan**

## Caution Advised

influenza vaccine + ibritumomab tiuxetan

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ibrutinib**

## Caution Advised

influenza vaccine + ibrutinib

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**idarubicin**

## Caution Advised

influenza vaccine + idarubicin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ifosfamide**

## Caution Advised

influenza vaccine + ifosfamide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**infliximab**

## Caution Advised

influenza vaccine + infliximab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**irinotecan**

## Caution Advised

influenza vaccine + irinotecan

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ixabepilone**

## Caution Advised

influenza vaccine + ixabepilone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**leflunomide**

## Caution Advised

influenza vaccine + leflunomide

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**lenalidomide**

## Caution Advised

influenza vaccine + lenalidomide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**lomustine**

## Caution Advised

influenza vaccine + lomustine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**lymphocyte immune globulin, antithymocyte globulin**

## Caution Advised

influenza vaccine + lymphocyte immune globulin, antithymocyte globulin

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mechlorethamine**

## Caution Advised

influenza vaccine + mechlorethamine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**melphalan**

## Caution Advised

influenza vaccine + melphalan

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mercaptopurine**

## Caution Advised

influenza vaccine + mercaptopurine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**methotrexate**

## Caution Advised

influenza vaccine + methotrexate

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**methylprednisolone**

## Caution Advised

influenza vaccine + methylprednisolone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mitomycin**

## Caution Advised

influenza vaccine + mitomycin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mitoxantrone**

## Caution Advised

influenza vaccine + mitoxantrone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**muromonab-CD3**

## Caution Advised

influenza vaccine + muromonab-CD3

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mycophenolate mofetil**

## Caution Advised

influenza vaccine + mycophenolate mofetil

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mycophenolic acid**

## Caution Advised

influenza vaccine + mycophenolic acid

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**natalizumab**

## Caution Advised

influenza vaccine + natalizumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**nelarabine**

## Caution Advised

influenza vaccine + nelarabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**obinutuzumab**

## Caution Advised

influenza vaccine + obinutuzumab

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic response to vaccine or toxoid (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ofatumumab**

## Caution Advised

influenza vaccine + ofatumumab

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**omacetaxine mepesuccinate**

## Caution Advised

influenza vaccine + omacetaxine mepesuccinate

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**oxaliplatin**

## Caution Advised

influenza vaccine + oxaliplatin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**paclitaxel**

## Caution Advised

influenza vaccine + paclitaxel

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**pemetrexed**

## Caution Advised

influenza vaccine + pemetrexed

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**pentostatin**

## Caution Advised

influenza vaccine + pentostatin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**pralatrexate**

## Caution Advised

influenza vaccine + pralatrexate

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**prednisolone**

## Caution Advised

influenza vaccine + prednisolone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**prednisone**

## Caution Advised

influenza vaccine + prednisone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ruxolitinib**

## Caution Advised

influenza vaccine + ruxolitinib

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**siltuximab**

## Caution Advised

influenza vaccine + siltuximab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**sirolimus**

## Caution Advised

influenza vaccine + sirolimus

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**tacrolimus**

## Caution Advised

influenza vaccine + tacrolimus

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**temozolomide**

## Caution Advised

influenza vaccine + temozolomide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**temsirolimus**

## Caution Advised

influenza vaccine + temsirolimus

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**teniposide**

## Caution Advised

influenza vaccine + teniposide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**teriflunomide**

## Caution Advised

influenza vaccine + teriflunomide

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**thioguanine**

## Caution Advised

influenza vaccine + thioguanine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**thiotepa**

## Caution Advised

influenza vaccine + thiotepa

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**tocilizumab**

## Caution Advised

influenza vaccine + tocilizumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**tofacitinib**

## Caution Advised

influenza vaccine + tofacitinib

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic response to vaccine or toxoid (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**topotecan**

## Caution Advised

influenza vaccine + topotecan

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**tositumomab**

## Caution Advised

influenza vaccine + tositumomab

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**triamcinolone**

## Caution Advised

influenza vaccine + triamcinolone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ustekinumab**

## Caution Advised

influenza vaccine + ustekinumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**vedolizumab**

## Caution Advised

influenza vaccine + vedolizumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**vinblastine**

## Caution Advised

influenza vaccine + vinblastine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**vincristine**

## Caution Advised

influenza vaccine + vincristine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**vinorelbine**

## Caution Advised

influenza vaccine + vinorelbine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

## Adverse Reactions .

### Serious Reactions

- hypersensitivity rxn
- anaphylaxis
- Guillain-Barre syndrome

### Common Reactions

- injection site rxn
- headache
- fatigue
- myalgia
- malaise
- arthralgia
- diaphoresis
- rigors
- URI sx

## Safety/Monitoring .

**Pregnancy:** B

**Lactation:** Safety Unknown

**Monitoring Parameters**

no routine tests recommended

## Pharmacology .

**Metabolism:** other; CYP450: unknown

**Excretion:** other; Half-life: unknown

**Subclass:**
Routine Adult Vaccines;
Influenza (Flu) Vaccines

**Mechanism of Action**

exact mechanism of action unknown; induces antibody formation

## Manufacturer/Pricing .

**Manufacturer:** Novartis Vaccines and Diagnostics, Inc.

**DEA/FDA: Rx**

### Approximate Retail Price

This information is currently not available for this drug.

### Join Now to View Patient Handouts!

Create a FREE Epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.

Current Members: Sign In.

## Pill Pictures

### Join Now to View Pill Pictures!

Create a FREE Epocrates Online account to access full-color images of medications within the drug monograph.

Current Members: Sign In.