# Flucelvax

## influenza A and B vaccine, inactivated trivalent

## Entire Monograph

## Adult Dosing .

**Dosage forms:** IM

### Vaccine Adverse Event Reporting

- [1-800-822-7967 or http://vaers.hhs.gov]

### immunization

- [0.5 mL IM x1 annually]
- Info: refer to Vaccinations: Routine Adult Immunization Schedule table and www.cdc.gov/flu for target populations and prioritization

### renal dosing

- [not defined]

### hepatic dosing

- [not defined]

## Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.

## Contraindications/Cautions .

- hypersens. to drug/class/compon.
- caution if hypersens. to latex
- caution if Guillain-Barre syndrome w/in 6wk of prior influenza vaccine
- caution if immunocompromised
- caution if acute illness, mod-severe

## Drug Interactions .

### Overview

**influenza vaccine**

- vaccine or toxoid

## Monitor/Modify Tx

- aminophylline
- fingolimod
- fosphenytoin
- phenytoin
- rituximab
- theophylline
- warfarin

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**aminophylline**

## Monitor/Modify Tx

influenza vaccine + aminophylline

**caution advised, monitor theophylline levels**: combo may incr. theophylline levels, risk of adverse effects (mechanism unknown, hepatic metab. possibly inhibited)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**fingolimod**

## Monitor/Modify Tx

influenza vaccine + fingolimod

**caution advised during fingolimod tx and x2mo after D/C, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**fosphenytoin**

## Monitor/Modify Tx

influenza vaccine + fosphenytoin

**caution advised, monitor phenytoin levels**: combo may incr. phenytoin levels, risk of toxicity (mechanism unknown, hepatic metab. possibly inhibited)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**phenytoin**

## Monitor/Modify Tx

influenza vaccine + phenytoin

**caution advised, monitor phenytoin levels**: combo may incr. phenytoin levels, risk of toxicity (mechanism unknown, hepatic metab. possibly inhibited)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**rituximab**

## Monitor/Modify Tx

influenza vaccine + rituximab

**vaccinate >4wk before rituximab course**: combo may result in inadequate immunologic response to vaccine or toxoid (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**theophylline**

## Monitor/Modify Tx

influenza vaccine + theophylline

**caution advised, monitor theophylline levels**: combo may incr. theophylline levels, risk of adverse effects (mechanism unknown, hepatic metab. possibly inhibited)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**warfarin**

## Monitor/Modify Tx

influenza vaccine + warfarin

**caution advised w/ IM injections when anticoagulated, monitor INR**: combo may incr. INR, risk of bleeding (mechanism unknown, hepatic metab. possibly inhibited)

## Caution Advised

- abatacept
- adalimumab
- aldesleukin
- alefacept
- alemtuzumab
- altretamine
- anakinra
- antithymocyte globulin
- azacitidine
- azathioprine
- basiliximab
- belatacept
- belimumab
- bendamustine
- betamethasone
- bleomycin
- busulfan
- cabazitaxel
- capecitabine
- carboplatin
- carmustine
- certolizumab pegol
- chlorambucil
- cisplatin
- cladribine
- cortisone
- cyclophosphamide
- cyclosporine
- cytarabine
- dacarbazine
- dactinomycin
- dasatinib
- daunorubicin
- decitabine
- dexamethasone
- docetaxel
- doxorubicin
- efalizumab
- epirubicin
- eribulin
- etanercept
- etoposide
- everolimus
- floxuridine
- fludarabine
- fluorouracil
- gemcitabine
- gemtuzumab ozogamicin
- golimumab
- hydrocortisone
- hydroxyurea
- ibritumomab tiuxetan
- ibrutinib
- idarubicin
- ifosfamide
- infliximab
- irinotecan
- ixabepilone
- leflunomide
- lenalidomide
- lomustine
- lymphocyte immune globulin, antithymocyte globulin
- mechlorethamine
- melphalan
- mercaptopurine
- methotrexate
- methylprednisolone
- mitomycin
- mitoxantrone
- muromonab-CD3
- mycophenolate mofetil
- mycophenolic acid
- natalizumab
- nelarabine
- obinutuzumab
- ofatumumab
- omacetaxine mepesuccinate
- oxaliplatin
- paclitaxel
- pemetrexed
- pentostatin
- pralatrexate
- prednisolone
- prednisone
- ruxolitinib
- sirolimus
- tacrolimus
- temozolomide
- temsirolimus
- teniposide
- teriflunomide
- thioguanine
- thiotepa
- tocilizumab
- tofacitinib
- topotecan
- tositumomab
- triamcinolone
- ustekinumab
- vinblastine
- vincristine
- vinorelbine

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**abatacept**

## Caution Advised

influenza vaccine + abatacept

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**adalimumab**

## Caution Advised

influenza vaccine + adalimumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**aldesleukin**

## Caution Advised

influenza vaccine + aldesleukin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**alefacept**

## Caution Advised

influenza vaccine + alefacept

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**alemtuzumab**

## Caution Advised

influenza vaccine + alemtuzumab

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**altretamine**

## Caution Advised

influenza vaccine + altretamine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**anakinra**

## Caution Advised

influenza vaccine + anakinra

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (interference w/ immune response mechanisms to new antigens)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**antithymocyte globulin**

## Caution Advised

influenza vaccine + antithymocyte globulin

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**azacitidine**

## Caution Advised

influenza vaccine + azacitidine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**azathioprine**

## Caution Advised

influenza vaccine + azathioprine

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**basiliximab**

## Caution Advised

influenza vaccine + basiliximab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**belatacept**

## Caution Advised

influenza vaccine + belatacept

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**belimumab**

## Caution Advised

influenza vaccine + belimumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**bendamustine**

## Caution Advised

influenza vaccine + bendamustine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**betamethasone**

## Caution Advised

influenza vaccine + betamethasone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**bleomycin**

## Caution Advised

influenza vaccine + bleomycin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine or toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**busulfan**

## Caution Advised

influenza vaccine + busulfan

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cabazitaxel**

## Caution Advised

influenza vaccine + cabazitaxel

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**capecitabine**

## Caution Advised

influenza vaccine + capecitabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**carboplatin**

## Caution Advised

influenza vaccine + carboplatin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**carmustine**

## Caution Advised

influenza vaccine + carmustine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**certolizumab pegol**

## Caution Advised

influenza vaccine + certolizumab pegol

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**chlorambucil**

## Caution Advised

influenza vaccine + chlorambucil

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cisplatin**

## Caution Advised

influenza vaccine + cisplatin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cladribine**

## Caution Advised

influenza vaccine + cladribine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cortisone**

## Caution Advised

influenza vaccine + cortisone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cyclophosphamide**

## Caution Advised

influenza vaccine + cyclophosphamide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cyclosporine**

## Caution Advised

influenza vaccine + cyclosporine

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**cytarabine**

## Caution Advised

influenza vaccine + cytarabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**dacarbazine**

## Caution Advised

influenza vaccine + dacarbazine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**dactinomycin**

## Caution Advised

influenza vaccine + dactinomycin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**dasatinib**

## Caution Advised

influenza vaccine + dasatinib

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**daunorubicin**

## Caution Advised

influenza vaccine + daunorubicin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**decitabine**

## Caution Advised

influenza vaccine + decitabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**dexamethasone**

## Caution Advised

influenza vaccine + dexamethasone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**docetaxel**

## Caution Advised

influenza vaccine + docetaxel

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**doxorubicin**

## Caution Advised

influenza vaccine + doxorubicin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**efalizumab**

## Caution Advised

influenza vaccine + efalizumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**epirubicin**

## Caution Advised

influenza vaccine + epirubicin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**eribulin**

## Caution Advised

influenza vaccine + eribulin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**etanercept**

## Caution Advised

influenza vaccine + etanercept

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**etoposide**

## Caution Advised

influenza vaccine + etoposide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**everolimus**

## Caution Advised

influenza vaccine + everolimus

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**floxuridine**

## Caution Advised

influenza vaccine + floxuridine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**fludarabine**

## Caution Advised

influenza vaccine + fludarabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**fluorouracil**

## Caution Advised

influenza vaccine + fluorouracil

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**gemcitabine**

## Caution Advised

influenza vaccine + gemcitabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**gemtuzumab ozogamicin**

## Caution Advised

influenza vaccine + gemtuzumab ozogamicin

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**golimumab**

## Caution Advised

influenza vaccine + golimumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**hydrocortisone**

## Caution Advised

influenza vaccine + hydrocortisone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**hydroxyurea**

## Caution Advised

influenza vaccine + hydroxyurea

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ibritumomab tiuxetan**

## Caution Advised

influenza vaccine + ibritumomab tiuxetan

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ibrutinib**

## Caution Advised

influenza vaccine + ibrutinib

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**idarubicin**

## Caution Advised

influenza vaccine + idarubicin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ifosfamide**

## Caution Advised

influenza vaccine + ifosfamide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**infliximab**

## Caution Advised

influenza vaccine + infliximab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**irinotecan**

## Caution Advised

influenza vaccine + irinotecan

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ixabepilone**

## Caution Advised

influenza vaccine + ixabepilone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**leflunomide**

## Caution Advised

influenza vaccine + leflunomide

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**lenalidomide**

## Caution Advised

influenza vaccine + lenalidomide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**lomustine**

## Caution Advised

influenza vaccine + lomustine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**lymphocyte immune globulin, antithymocyte globulin**

## Caution Advised

influenza vaccine + lymphocyte immune globulin, antithymocyte globulin

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mechlorethamine**

## Caution Advised

influenza vaccine + mechlorethamine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**melphalan**

## Caution Advised

influenza vaccine + melphalan

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mercaptopurine**

## Caution Advised

influenza vaccine + mercaptopurine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**methotrexate**

## Caution Advised

influenza vaccine + methotrexate

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**methylprednisolone**

## Caution Advised

influenza vaccine + methylprednisolone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mitomycin**

## Caution Advised

influenza vaccine + mitomycin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mitoxantrone**

## Caution Advised

influenza vaccine + mitoxantrone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**muromonab-CD3**

## Caution Advised

influenza vaccine + muromonab-CD3

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mycophenolate mofetil**

## Caution Advised

influenza vaccine + mycophenolate mofetil

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**mycophenolic acid**

## Caution Advised

influenza vaccine + mycophenolic acid

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**natalizumab**

## Caution Advised

influenza vaccine + natalizumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**nelarabine**

## Caution Advised

influenza vaccine + nelarabine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**obinutuzumab**

## Caution Advised

influenza vaccine + obinutuzumab

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic response to vaccine or toxoid (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ofatumumab**

## Caution Advised

influenza vaccine + ofatumumab

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**omacetaxine mepesuccinate**

## Caution Advised

influenza vaccine + omacetaxine mepesuccinate

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**oxaliplatin**

## Caution Advised

influenza vaccine + oxaliplatin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**paclitaxel**

## Caution Advised

influenza vaccine + paclitaxel

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**pemetrexed**

## Caution Advised

influenza vaccine + pemetrexed

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**pentostatin**

## Caution Advised

influenza vaccine + pentostatin

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**pralatrexate**

## Caution Advised

influenza vaccine + pralatrexate

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**prednisolone**

## Caution Advised

influenza vaccine + prednisolone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**prednisone**

## Caution Advised

influenza vaccine + prednisone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ruxolitinib**

## Caution Advised

influenza vaccine + ruxolitinib

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**sirolimus**

## Caution Advised

influenza vaccine + sirolimus

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**tacrolimus**

## Caution Advised

influenza vaccine + tacrolimus

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**temozolomide**

## Caution Advised

influenza vaccine + temozolomide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**temsirolimus**

## Caution Advised

influenza vaccine + temsirolimus

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**teniposide**

## Caution Advised

influenza vaccine + teniposide

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**teriflunomide**

## Caution Advised

influenza vaccine + teriflunomide

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**thioguanine**

## Caution Advised

influenza vaccine + thioguanine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**thiotepa**

## Caution Advised

influenza vaccine + thiotepa

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**tocilizumab**

## Caution Advised

influenza vaccine + tocilizumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**tofacitinib**

## Caution Advised

influenza vaccine + tofacitinib

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic response to vaccine or toxoid (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**topotecan**

## Caution Advised

influenza vaccine + topotecan

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**tositumomab**

## Caution Advised

influenza vaccine + tositumomab

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**triamcinolone**

## Caution Advised

influenza vaccine + triamcinolone

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**ustekinumab**

## Caution Advised

influenza vaccine + ustekinumab

**caution advised, consider post-immunization titer check**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**vinblastine**

## Caution Advised

influenza vaccine + vinblastine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**vincristine**

## Caution Advised

influenza vaccine + vincristine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

**Flucelvax**(influenza A and B vaccine, inactivated trivalent)

**vinorelbine**

## Caution Advised

influenza vaccine + vinorelbine

**caution advised, consider post-immunization titer check if recent or current immunosuppressive tx**: combo may result in inadequate immunologic vaccine/toxoid response (immunosuppressive effects)

## Adverse Reactions .

### Serious Reactions

- hypersensitivity rxn
- anaphylaxis
- Guillain-Barre syndrome

### Common Reactions

- injection site rxn
- headache
- fatigue
- myalgia
- malaise
- arthralgia
- diaphoresis
- rigors
- URI sx

## Safety/Monitoring .

**Pregnancy:** B

**Lactation:** Safety Unknown

**Monitoring Parameters**

no routine tests recommended

## Pharmacology .

**Metabolism:** other; CYP450: unknown

**Excretion:** other; Half-life: unknown

**Subclass:**
Routine Adult Vaccines;
Influenza (Flu) Vaccines

**Mechanism of Action**

exact mechanism of action unknown; induces antibody formation

## Manufacturer/Pricing .

**Manufacturer:** Novartis Vaccines and Diagnostics, Inc.

**DEA/FDA: Rx**

### Approximate Retail Price

This information is currently not available for this drug.

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