Adult Dosing .
Dosage forms: IV
intra-abdominal infections, complicated
- [500 mg IV q8h x5-14 days]
- Info: duration varies by infection site/severity; after 3 days may switch to appropriate PO tx if clinical improvement
- [500 mg IV q8h x10 days]
- Info: duration varies by infection site/severity; may extend to 14 days if concurrent bacteremia
- [adjust dose amount, frequency]
- CrCl 30-50: 250 mg IV q8h; CrCl 10-30: 250 mg IV q12h; CrCl <10: not defined; HD: not defined
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
- hypersens. to drug/class/compon.
- anaphylactic rxn to beta-lactams
- inhalational use
- ventilator-assoc. pneumonia use
- caution if hypersens. to beta-lactams
- caution if hypersens. to multiple allergens
- caution if renal impairment
- caution if CNS disorder
- caution if seizure hx
- caution if seizure risk
- caution if recent abx-assoc. colitis hx
Drug Interactions .
- valproic acid
Adverse Reactions .
- hypersensitivity rxn
- anaphylaxis/anaphylactoid rxn
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- C. difficile-assoc. diarrhea
- pneumonia, interstitial
- ALT, AST elevated
- candidiasis, vulvovaginal
Lactation: Safety Unknown
Cr at baseline, then if moderate-severe renal impairment cont. periodically
Metabolism: kidney minimally; CYP450: none
Excretion: urine 85% (70% unchanged), feces <1%; Half-life: 1h; Info: undergoes active tubular secretion
Mechanism of Action
bactericidal; inhibits cell wall synthesis
Manufacturer: Janssen Pharmaceuticals, Inc.
Approximate Retail Price
This information is currently not available for this drug.
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