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Adult Dosing .
Dosage forms: 1
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
breast CA, advanced or metastatic postmenopausal
- [1 mg PO qd]
early postmenopausal breast CA, adjuvant tx
- [1 mg PO qd]
- [1-5 mg PO qd x5 days]
- Start: day 3 of menstrual cycle
- [no adjustment]
- [see below]
- mild-mod impairment/cirrhosis: no adjustment; severe impairment: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
- hypersens. to drug/class/compon.
- premenopausal pts
- caution if ischemic heart dz
Drug Interactions .
- estradiol (contraceptive)
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- estropipate (hormone replacement)
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- mestranol (contraceptive)
Adverse Reactions .
- endometrial CA
- erythema multiforme
- Stevens-Johnson syndrome
- hot flashes
- weight gain
- abdominal pain
- bone pain
- breast pain
Lactation: Safety Unknown
pregnancy test at baseline; consider BMD, lipid panel
Look/Sound-Alike Drug Names
anastrozole confused with: anagrelide; letrozole
Metabolism: liver primarily; CYP450: none
Excretion: urine 60% (10% unchanged), feces; Half-life: 50h
Mechanism of Action
inhibits enzymatic androgen conversion to estrogen, reducing hormone receptor positive cancer cell growth (aromatase inhibitor)
Approximate Retail Price
- 1 mg (30 ea): $384.84
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