Adult Dosing .
Dosage forms: 200
Parkinson dz, adjunct tx
- [200 mg PO bid-qid]
- Max: 1600 mg/day; Info: give w/ each carbidopa/levodopa dose; taper dose gradually to D/C
- [not defined]
- [not defined]
- hepatic impairment: caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
- hypersens. to drug/class/compon.
- avoid abrupt withdrawal
- caution if concurrent CNS depressant use
- caution if alcohol use
- caution if hepatic impairment
- caution if psychosis hx
Drug Interactions .
- selegiline transdermal
- epinephrine inhaled
- milk thistle
- phenylephrine injection
Adverse Reactions .
- hypotension, orthostatic
- fibrotic complications
- NMS-like sx if abrupt D/C
- urine discoloration
- abdominal pain
- back pain
- mood changes
- compulsive behaviors
Lactation: Safety Unknown
BP esp. during initial tx; dermatologic exams
Metabolism: isomerization and glucuronidation; CYP450: unknown
Excretion: feces 90%, urine 10% (0.2% unchanged); Half-life: 2.4h
Subclass: Parkinson Dz/Dystonia
Mechanism of Action
selectively inhibits peripheral catechol O-methyltransferase (COMT), increasing central bioavailability of levodopa
Approximate Retail Price
This information is currently not available for this drug.
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