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Humulin R
insulin regular
Adult Dosing .
Dosage forms: INJ (U-100 vial): 100 units per mL; INJ (U-500 vial): 500 units per mL; INJ (KwikPen U-500 pen): 500 units per mL
Special Note
- [strength clarification]
- Info: U-500 strength for SC use only
- [additional info]
- Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility
diabetes mellitus, type 1
- [SC route, U-100 strength]
- Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); give 30min before meals; use w/ intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.5-1h, peak 2-4h, duration 6-12h (short-acting insulin)
- [SC route, U-500 strength]
- Dose: individualize dose SC bid-tid; Info: for pts requiring >200 units/day; give 30min before meals; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.5-1h, peak 2-4h, duration up to 24h (short to intermediate-acting insulin)
- [IV route, U-100 strength]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)
diabetes mellitus, type 2
- [SC route, U-100 strength]
- Dose: individualize dose SC bid-qid; Start: 4 units SC qd or 10% of basal insulin dose SC qd, may incr. dose by 1-2 units or 10-15% 2x/wk; Info: give 30min before meals; use w/ intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.5-1h, peak 2-4h, duration 6-12h (short-acting insulin)
- [SC route, U-500 strength]
- Dose: individualize dose SC bid-tid; Info: for pts requiring >200 units/day; give 30min before meals; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.5-1h, peak 2-4h, duration up to 24h (short to intermediate-acting insulin)
- [IV route, U-100 strength]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)
diabetic ketoacidosis (off-label)
- [U-100 strength]
- Dose: 0.1 units/kg/dose IV x1, then 0.1 units/kg/h IV; Alt: 0.14 units/kg/h IV; Info: if blood glucose decr. by <10% in 1st hour, give 0.14 units/kg/dose IV x1, then resume usual dose; when blood glucose 200 mg/dL, decr. dose to 0.02-0.05 units/kg/h IV; maintain blood glucose at 150-200 mg/dL until DKA resolves
hyperkalemia (off-label)
- [U-100 strength]
- Dose: 10 units IV x1; Info: give w/ D50W
renal dosing
- [see below]
- renal impairment: consider decr. usual start dose
- HD/PD: consider decr. usual start dose; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ (U-100 vial): 100 units per mL; INJ (U-500 vial): 500 units per mL; INJ (KwikPen U-500 pen): 500 units per mL
Special Note
- [strength clarification]
- Info: U-500 strength for SC use only
- [additional info]
- Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility
diabetes mellitus, type 1
- [SC route, U-100 strength]
- Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; give 30min before meals; use w/ intermediate-acting or long-acting insulin; onset 0.5-1h, peak 2-4h, duration 6-12h (short-acting insulin)
- [SC route, U-500 strength]
- Dose: individualize dose SC bid-tid; Info: for pts requiring >200 units/day; give 30min before meals; onset 0.5-1h, peak 2-4h, duration up to 24h (short to intermediate-acting insulin)
- [IV route, U-100 strength]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)
diabetes mellitus, type 2
- [SC route, U-100 strength]
- Dose: individualize dose SC bid-qid; Info: give 30min before meals; use w/ intermediate-acting or long-acting insulin; onset 0.5-1h, peak 2-4h, duration 6-12h (short-acting insulin)
- [SC route, U-500 strength]
- Dose: individualize dose SC bid-tid; Info: for pts requiring >200 units/day; give 30min before meals; onset 0.5-1h, peak 2-4h, duration up to 24h (short to intermediate-acting insulin)
- [IV route, U-100 strength]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)
diabetic ketoacidosis (off-label)
- [U-100 strength]
- Dose: 0.1 units/kg/h IV; Start: 1-2h after initial fluid tx; Info: give w/ IV potassium; for pts w/ marked insulin sensitivity, may decr. dose to <0.05 units/kg/h IV; add dextrose 5% when blood glucose 250-300 mg/dL or if blood glucose decr. at rate >90 mg/dL/h; maintain blood glucose at 200-250 mg/dL until DKA resolves; start insulin SC injection 1h before D/C insulin IV
hyperkalemia (off-label)
- [U-100 strength, <1 mo]
- Dose: 0.1-0.2 units/kg/h IV; Info: give w/ dextrose; refer to institution protocol
- [U-100 strength, 1 mo and older]
- Dose: 0.05-0.1 units/kg/h IV; Info: give w/ dextrose; refer to institution protocol
renal dosing
- [see below]
- renal impairment: consider decr. usual start dose
- HD/PD: consider decr. usual start dose; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised