## Select a medication above to begin.

# Thalomid

## thalidomide

## Drug Interactions .

### Overview

**thalidomide**

- CYP2C19 substrate
- CNS depression
- thrombogenic effects

## Avoid/Use Alternative

- aminocaproic acid
- carbinoxamine
- coagulation factor VIIa
- doxylamine
- lenalidomide
- natalizumab
- pomalidomide
- sodium oxybate
- tranexamic acid

**Thalomid**(thalidomide)

**aminocaproic acid**

## Avoid/Use Alternative

thalidomide + aminocaproic acid

**avoid combo**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**carbinoxamine**

## Avoid/Use Alternative

thalidomide + carbinoxamine

**avoid combo**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**coagulation factor VIIa**

## Avoid/Use Alternative

thalidomide + coagulation factor VIIa

**avoid combo**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**doxylamine**

## Avoid/Use Alternative

thalidomide + doxylamine

**avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**lenalidomide**

## Avoid/Use Alternative

thalidomide + lenalidomide

**avoid combo**: combo may incr. risk of adverse effects (additive effects, duplicate tx)

**Thalomid**(thalidomide)

**natalizumab**

## Avoid/Use Alternative

thalidomide + natalizumab

**avoid combo**: combo may incr. risk of infection, including PML (additive effects)

**Thalomid**(thalidomide)

**pomalidomide**

## Avoid/Use Alternative

thalidomide + pomalidomide

**avoid combo**: combo may incr. risk of adverse effects (additive effects, duplicate tx)

**Thalomid**(thalidomide)

**sodium oxybate**

## Avoid/Use Alternative

thalidomide + sodium oxybate

**avoid combo**: combo may incr. risk of CNS depression, other adverse effects (additive effects)

**Thalomid**(thalidomide)

**tranexamic acid**

## Avoid/Use Alternative

thalidomide + tranexamic acid

**avoid combo**: combo may incr. thrombosis risk (additive effects)

## Monitor/Modify Tx

- dexmedetomidine
- pamidronate
- suvorexant

**Thalomid**(thalidomide)

**dexmedetomidine**

## Monitor/Modify Tx

thalidomide + dexmedetomidine

**caution advised, consider dose reduction**: combo may incr. risk of CNS and respiratory depression, other adverse effects (additive effects)

**Thalomid**(thalidomide)

**pamidronate**

## Monitor/Modify Tx

thalidomide + pamidronate

**caution advised in multiple myeloma pts, monitor renal fxn**: combo may incr. risk of nephrotoxicity (additive toxicity)

**Thalomid**(thalidomide)

**suvorexant**

## Monitor/Modify Tx

thalidomide + suvorexant

**caution advised, consider dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

## Caution Advised

- acrivastine
- aldesleukin
- alfentanil
- alprazolam
- amitriptyline
- amoxapine
- anti-inhibitor coagulant complex
- antihemophilic factor (factor VIII)/von Willebrand factor complex
- apomorphine
- aripiprazole
- asenapine
- asparaginase
- axitinib
- azelastine nasal
- baclofen
- baclofen intrathecal
- bevacizumab
- brompheniramine
- buprenorphine
- butabarbital
- butalbital
- butorphanol
- butorphanol nasal
- C1 esterase inhibitor
- cabozantinib
- carbamazepine
- carisoprodol
- cetirizine
- chloral hydrate
- chlordiazepoxide
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- chorionic gonadotropin
- clemastine
- clobazam
- clomipramine
- clonazepam
- clorazepate
- clozapine
- coagulation factor IX
- codeine
- cyclizine
- cyclobenzaprine
- cyproheptadine
- dantrolene
- darbepoetin alfa
- desipramine
- dexchlorpheniramine
- diazepam
- dichloralphenazone
- dihydrocodeine
- dimenhydrinate
- diphenhydramine
- doxepin
- dronabinol
- epoetin alfa
- erlotinib
- eslicarbazepine acetate
- estazolam
- estradiol (contraceptive)
- estradiol (hormone replacement)
- estramustine
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- estropipate (hormone replacement)
- eszopiclone
- ethanol
- ethanol (in some formulations)
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- ethosuximide
- ezogabine
- factor XIII concentrate
- fentanyl
- fluphenazine
- flurazepam
- fospropofol
- gabapentin
- gabapentin enacarbil
- haloperidol
- hydrocodone
- hydromorphone
- hydroxyzine
- iloperidone
- imipramine
- lenvatinib
- levocetirizine
- levorphanol
- lorazepam
- loxapine
- lurasidone
- maprotiline
- meclizine
- medroxyprogesterone (contraceptive)
- medroxyprogesterone (hormone replacement)
- meperidine
- meprobamate
- mestranol (contraceptive)
- metaxalone
- methadone
- methocarbamol
- methohexital
- methoxy polyethylene glycol-epoetin beta
- methsuximide
- midazolam
- mirtazapine
- mitotane
- morphine
- morphine liposomal
- nabilone
- nalbuphine
- nefazodone
- nintedanib
- norethindrone (contraceptive)
- norethindrone acetate (hormone replacement)
- nortriptyline
- olanzapine
- orphenadrine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- paliperidone
- pegaspargase
- pentazocine
- pentobarbital
- perampanel
- perphenazine
- pheniramine
- phenobarbital
- pimozide
- ponatinib
- pramipexole
- pregabalin
- primidone
- prochlorperazine
- promethazine
- propofol
- protriptyline
- pyrilamine
- quetiapine
- raloxifene
- ramucirumab
- remifentanil
- risperidone
- ropinirole
- rotigotine transdermal
- rufinamide
- secobarbital
- sufentanil
- tamoxifen
- tapentadol
- temazepam
- tetrabenazine
- thioridazine
- thiothixene
- tizanidine
- tolcapone
- topiramate
- tramadol
- trazodone
- tretinoin
- triazolam
- trifluoperazine
- trimipramine
- triprolidine
- valproic acid
- vigabatrin
- vorinostat
- zaleplon
- ziconotide
- ziprasidone
- ziv-aflibercept
- zoledronic acid
- zolpidem
- zonisamide

**Thalomid**(thalidomide)

**acrivastine**

## Caution Advised

thalidomide + acrivastine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**aldesleukin**

## Caution Advised

thalidomide + aldesleukin

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**alfentanil**

## Caution Advised

thalidomide + alfentanil

**caution advised, consider opioid dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**alprazolam**

## Caution Advised

thalidomide + alprazolam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**amitriptyline**

## Caution Advised

thalidomide + amitriptyline

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**amoxapine**

## Caution Advised

thalidomide + amoxapine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**anti-inhibitor coagulant complex**

## Caution Advised

thalidomide + anti-inhibitor coagulant complex

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**antihemophilic factor (factor VIII)/ von Willebrand factor complex**

## Caution Advised

thalidomide + antihemophilic factor (factor VIII)/ von Willebrand factor complex

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**apomorphine**

## Caution Advised

thalidomide + apomorphine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive/synergistic effects)

**Thalomid**(thalidomide)

**aripiprazole**

## Caution Advised

thalidomide + aripiprazole

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**asenapine**

## Caution Advised

thalidomide + asenapine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**asparaginase**

## Caution Advised

thalidomide + asparaginase

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**axitinib**

## Caution Advised

thalidomide + axitinib

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**azelastine nasal**

## Caution Advised

thalidomide + azelastine nasal

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**baclofen**

## Caution Advised

thalidomide + baclofen

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**baclofen intrathecal**

## Caution Advised

thalidomide + baclofen intrathecal

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**bevacizumab**

## Caution Advised

thalidomide + bevacizumab

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**brompheniramine**

## Caution Advised

thalidomide + brompheniramine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**buprenorphine**

## Caution Advised

thalidomide + buprenorphine

**caution advised, consider dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**butabarbital**

## Caution Advised

thalidomide + butabarbital

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**butalbital**

## Caution Advised

thalidomide + butalbital

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**butorphanol**

## Caution Advised

thalidomide + butorphanol

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**butorphanol nasal**

## Caution Advised

thalidomide + butorphanol nasal

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**C1 esterase inhibitor**

## Caution Advised

thalidomide + C1 esterase inhibitor

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**cabozantinib**

## Caution Advised

thalidomide + cabozantinib

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**carbamazepine**

## Caution Advised

thalidomide + carbamazepine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**carisoprodol**

## Caution Advised

thalidomide + carisoprodol

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**cetirizine**

## Caution Advised

thalidomide + cetirizine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**chloral hydrate**

## Caution Advised

thalidomide + chloral hydrate

**caution advised, consider sedative/hypnotic dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**chlordiazepoxide**

## Caution Advised

thalidomide + chlordiazepoxide

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**chlorpheniramine**

## Caution Advised

thalidomide + chlorpheniramine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**chlorpromazine**

## Caution Advised

thalidomide + chlorpromazine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**chlorzoxazone**

## Caution Advised

thalidomide + chlorzoxazone

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**chorionic gonadotropin**

## Caution Advised

thalidomide + chorionic gonadotropin

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**clemastine**

## Caution Advised

thalidomide + clemastine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**clobazam**

## Caution Advised

thalidomide + clobazam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**clomipramine**

## Caution Advised

thalidomide + clomipramine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**clonazepam**

## Caution Advised

thalidomide + clonazepam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**clorazepate**

## Caution Advised

thalidomide + clorazepate

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**clozapine**

## Caution Advised

thalidomide + clozapine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**coagulation factor IX**

## Caution Advised

thalidomide + coagulation factor IX

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**codeine**

## Caution Advised

thalidomide + codeine

**caution advised, consider opioid dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**cyclizine**

## Caution Advised

thalidomide + cyclizine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**cyclobenzaprine**

## Caution Advised

thalidomide + cyclobenzaprine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**cyproheptadine**

## Caution Advised

thalidomide + cyproheptadine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**dantrolene**

## Caution Advised

thalidomide + dantrolene

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**darbepoetin alfa**

## Caution Advised

thalidomide + darbepoetin alfa

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**desipramine**

## Caution Advised

thalidomide + desipramine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**dexchlorpheniramine**

## Caution Advised

thalidomide + dexchlorpheniramine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**diazepam**

## Caution Advised

thalidomide + diazepam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**dichloralphenazone**

## Caution Advised

thalidomide + dichloralphenazone

**caution advised, consider sedative/hypnotic dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**dihydrocodeine**

## Caution Advised

thalidomide + dihydrocodeine

**caution advised, consider opioid dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**dimenhydrinate**

## Caution Advised

thalidomide + dimenhydrinate

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**diphenhydramine**

## Caution Advised

thalidomide + diphenhydramine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**doxepin**

## Caution Advised

thalidomide + doxepin

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**dronabinol**

## Caution Advised

thalidomide + dronabinol

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**epoetin alfa**

## Caution Advised

thalidomide + epoetin alfa

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**erlotinib**

## Caution Advised

thalidomide + erlotinib

**caution advised**: combo may incr. risk of GI perforation (additive anti-angiogenic effects)

**Thalomid**(thalidomide)

**eslicarbazepine acetate**

## Caution Advised

thalidomide + eslicarbazepine acetate

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**estazolam**

## Caution Advised

thalidomide + estazolam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**estradiol (contraceptive)**

## Caution Advised

thalidomide + estradiol (contraceptive)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**estradiol (hormone replacement)**

## Caution Advised

thalidomide + estradiol (hormone replacement)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**estramustine**

## Caution Advised

thalidomide + estramustine

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**estrogens, conjugated (hormone replacement)**

## Caution Advised

thalidomide + estrogens, conjugated (hormone replacement)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**estrogens, esterified (hormone replacement)**

## Caution Advised

thalidomide + estrogens, esterified (hormone replacement)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**estropipate (hormone replacement)**

## Caution Advised

thalidomide + estropipate (hormone replacement)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**eszopiclone**

## Caution Advised

thalidomide + eszopiclone

**caution advised, consider sedative/hypnotic dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**ethanol**

## Caution Advised

thalidomide + ethanol

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**ethanol (in some formulations)**

## Caution Advised

thalidomide + ethanol (in some formulations)

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**ethinyl estradiol (contraceptive)**

## Caution Advised

thalidomide + ethinyl estradiol (contraceptive)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**ethinyl estradiol (hormone replacement)**

## Caution Advised

thalidomide + ethinyl estradiol (hormone replacement)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**ethosuximide**

## Caution Advised

thalidomide + ethosuximide

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**ezogabine**

## Caution Advised

thalidomide + ezogabine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**factor XIII concentrate**

## Caution Advised

thalidomide + factor XIII concentrate

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**fentanyl**

## Caution Advised

thalidomide + fentanyl

**caution advised, consider dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**fluphenazine**

## Caution Advised

thalidomide + fluphenazine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**flurazepam**

## Caution Advised

thalidomide + flurazepam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**fospropofol**

## Caution Advised

thalidomide + fospropofol

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**gabapentin**

## Caution Advised

thalidomide + gabapentin

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**gabapentin enacarbil**

## Caution Advised

thalidomide + gabapentin enacarbil

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**haloperidol**

## Caution Advised

thalidomide + haloperidol

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**hydrocodone**

## Caution Advised

thalidomide + hydrocodone

**caution advised, consider opioid dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**hydromorphone**

## Caution Advised

thalidomide + hydromorphone

**caution advised, consider dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**hydroxyzine**

## Caution Advised

thalidomide + hydroxyzine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**iloperidone**

## Caution Advised

thalidomide + iloperidone

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**imipramine**

## Caution Advised

thalidomide + imipramine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**lenvatinib**

## Caution Advised

thalidomide + lenvatinib

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**levocetirizine**

## Caution Advised

thalidomide + levocetirizine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**levorphanol**

## Caution Advised

thalidomide + levorphanol

**caution advised, consider opioid dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**lorazepam**

## Caution Advised

thalidomide + lorazepam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**loxapine**

## Caution Advised

thalidomide + loxapine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**lurasidone**

## Caution Advised

thalidomide + lurasidone

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**maprotiline**

## Caution Advised

thalidomide + maprotiline

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**meclizine**

## Caution Advised

thalidomide + meclizine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**medroxyprogesterone (contraceptive)**

## Caution Advised

thalidomide + medroxyprogesterone (contraceptive)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**medroxyprogesterone (hormone replacement)**

## Caution Advised

thalidomide + medroxyprogesterone (hormone replacement)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**meperidine**

## Caution Advised

thalidomide + meperidine

**caution advised, consider opioid dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**meprobamate**

## Caution Advised

thalidomide + meprobamate

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**mestranol (contraceptive)**

## Caution Advised

thalidomide + mestranol (contraceptive)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**metaxalone**

## Caution Advised

thalidomide + metaxalone

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**methadone**

## Caution Advised

thalidomide + methadone

**caution advised, consider dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**methocarbamol**

## Caution Advised

thalidomide + methocarbamol

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**methohexital**

## Caution Advised

thalidomide + methohexital

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**methoxy polyethylene glycol-epoetin beta**

## Caution Advised

thalidomide + methoxy polyethylene glycol-epoetin beta

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**methsuximide**

## Caution Advised

thalidomide + methsuximide

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**midazolam**

## Caution Advised

thalidomide + midazolam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**mirtazapine**

## Caution Advised

thalidomide + mirtazapine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**mitotane**

## Caution Advised

thalidomide + mitotane

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**morphine**

## Caution Advised

thalidomide + morphine

**caution advised, consider dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**morphine liposomal**

## Caution Advised

thalidomide + morphine liposomal

**caution advised**: combo may incr. risk of CNS depression, profound sedation, hypotension, other adverse effects (additive effects)

**Thalomid**(thalidomide)

**nabilone**

## Caution Advised

thalidomide + nabilone

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**nalbuphine**

## Caution Advised

thalidomide + nalbuphine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**nefazodone**

## Caution Advised

thalidomide + nefazodone

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**nintedanib**

## Caution Advised

thalidomide + nintedanib

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**norethindrone (contraceptive)**

## Caution Advised

thalidomide + norethindrone (contraceptive)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**norethindrone acetate (hormone replacement)**

## Caution Advised

thalidomide + norethindrone acetate (hormone replacement)

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**nortriptyline**

## Caution Advised

thalidomide + nortriptyline

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**olanzapine**

## Caution Advised

thalidomide + olanzapine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**orphenadrine**

## Caution Advised

thalidomide + orphenadrine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**oxazepam**

## Caution Advised

thalidomide + oxazepam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**oxcarbazepine**

## Caution Advised

thalidomide + oxcarbazepine

**caution advised**: combo may incr. thalidomide levels, risk of adverse effects; may incr. risk of CNS depression, psychomotor impairment (hepatic metab. inhibited; additive effects)

**Thalomid**(thalidomide)

**oxybutynin**

## Caution Advised

thalidomide + oxybutynin

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**oxycodone**

## Caution Advised

thalidomide + oxycodone

**caution advised, consider dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**oxymorphone**

## Caution Advised

thalidomide + oxymorphone

**caution advised, consider dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**paliperidone**

## Caution Advised

thalidomide + paliperidone

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**pegaspargase**

## Caution Advised

thalidomide + pegaspargase

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**pentazocine**

## Caution Advised

thalidomide + pentazocine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**pentobarbital**

## Caution Advised

thalidomide + pentobarbital

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**perampanel**

## Caution Advised

thalidomide + perampanel

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**perphenazine**

## Caution Advised

thalidomide + perphenazine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**pheniramine**

## Caution Advised

thalidomide + pheniramine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**phenobarbital**

## Caution Advised

thalidomide + phenobarbital

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**pimozide**

## Caution Advised

thalidomide + pimozide

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**ponatinib**

## Caution Advised

thalidomide + ponatinib

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**pramipexole**

## Caution Advised

thalidomide + pramipexole

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**pregabalin**

## Caution Advised

thalidomide + pregabalin

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment, adverse effects (additive effects)

**Thalomid**(thalidomide)

**primidone**

## Caution Advised

thalidomide + primidone

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**prochlorperazine**

## Caution Advised

thalidomide + prochlorperazine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**promethazine**

## Caution Advised

thalidomide + promethazine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**propofol**

## Caution Advised

thalidomide + propofol

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**protriptyline**

## Caution Advised

thalidomide + protriptyline

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**pyrilamine**

## Caution Advised

thalidomide + pyrilamine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**quetiapine**

## Caution Advised

thalidomide + quetiapine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**raloxifene**

## Caution Advised

thalidomide + raloxifene

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**ramucirumab**

## Caution Advised

thalidomide + ramucirumab

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**remifentanil**

## Caution Advised

thalidomide + remifentanil

**caution advised, consider opioid dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**risperidone**

## Caution Advised

thalidomide + risperidone

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**ropinirole**

## Caution Advised

thalidomide + ropinirole

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**rotigotine transdermal**

## Caution Advised

thalidomide + rotigotine transdermal

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**rufinamide**

## Caution Advised

thalidomide + rufinamide

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**secobarbital**

## Caution Advised

thalidomide + secobarbital

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**sufentanil**

## Caution Advised

thalidomide + sufentanil

**caution advised, consider opioid dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**tamoxifen**

## Caution Advised

thalidomide + tamoxifen

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**tapentadol**

## Caution Advised

thalidomide + tapentadol

**caution advised, consider dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**temazepam**

## Caution Advised

thalidomide + temazepam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**tetrabenazine**

## Caution Advised

thalidomide + tetrabenazine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**thioridazine**

## Caution Advised

thalidomide + thioridazine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**thiothixene**

## Caution Advised

thalidomide + thiothixene

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**tizanidine**

## Caution Advised

thalidomide + tizanidine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**tolcapone**

## Caution Advised

thalidomide + tolcapone

**caution advised**: combo may incr. risk of CNS depression, other adverse effects (additive effects)

**Thalomid**(thalidomide)

**topiramate**

## Caution Advised

thalidomide + topiramate

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**tramadol**

## Caution Advised

thalidomide + tramadol

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**trazodone**

## Caution Advised

thalidomide + trazodone

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**tretinoin**

## Caution Advised

thalidomide + tretinoin

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**triazolam**

## Caution Advised

thalidomide + triazolam

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**trifluoperazine**

## Caution Advised

thalidomide + trifluoperazine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**trimipramine**

## Caution Advised

thalidomide + trimipramine

**caution advised**: combo may incr. risk of CNS depression (additive effects)

**Thalomid**(thalidomide)

**triprolidine**

## Caution Advised

thalidomide + triprolidine

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**valproic acid**

## Caution Advised

thalidomide + valproic acid

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**vigabatrin**

## Caution Advised

thalidomide + vigabatrin

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**vorinostat**

## Caution Advised

thalidomide + vorinostat

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**zaleplon**

## Caution Advised

thalidomide + zaleplon

**caution advised, consider sedative/hypnotic dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**ziconotide**

## Caution Advised

thalidomide + ziconotide

**caution advised**: combo may incr. risk of confusion, dizziness, other CNS adverse effects (additive effects)

**Thalomid**(thalidomide)

**ziprasidone**

## Caution Advised

thalidomide + ziprasidone

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**ziv-aflibercept**

## Caution Advised

thalidomide + ziv-aflibercept

**caution advised**: combo may incr. thrombosis risk (additive effects)

**Thalomid**(thalidomide)

**zoledronic acid**

## Caution Advised

thalidomide + zoledronic acid

**caution advised in multiple myeloma pts, monitor renal fxn**: combo may incr. risk of nephrotoxicity (additive toxicity)

**Thalomid**(thalidomide)

**zolpidem**

## Caution Advised

thalidomide + zolpidem

**caution advised, consider sedative/hypnotic dose reduction**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

**Thalomid**(thalidomide)

**zonisamide**

## Caution Advised

thalidomide + zonisamide

**caution advised**: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)