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Advil Sinus Congestion & Pain
ibuprofen/ phenylephrine
Uses .
- [ ibuprofen ]
- NSAID for reducing pain/inflammation, fever
- [ phenylephrine ]
- decongestant for reducing nasal/sinus stuffiness
Dosing
This information is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient ( phenylephrine; ibuprofen )
- hypersensitivity to ASA ( ibuprofen )
- hypersensitivity to NSAIDs ( ibuprofen )
- aspirin triad ( ibuprofen )
- asthma, ASA-induced ( ibuprofen )
- asthma, NSAID-induced ( ibuprofen )
- CABG surgery periop use ( ibuprofen )
- CAD ( phenylephrine )
- CHF, severe ( ibuprofen )
- CrCl <30 ( ibuprofen )
- GI bleeding ( ibuprofen )
- GI bleeding hx ( ibuprofen )
- HTN, severe ( phenylephrine )
- HTN, uncontrolled ( phenylephrine )
- MAO inhibitor use w/in 14 days ( phenylephrine )
- MI, recent ( ibuprofen )
- pregnancy 1st trimester ( phenylephrine )
- pregnancy starting at 30 wk gestation ( ibuprofen )
- PUD hx ( ibuprofen )
- renal dz, advanced ( ibuprofen )
- urinary retention ( phenylephrine )
- urticaria, ASA-induced ( ibuprofen )
- urticaria, NSAID-induced ( ibuprofen )
- caution: alcohol use, concurrent ( ibuprofen )
- caution: arrhythmia ( phenylephrine )
- caution: asthma ( ibuprofen )
- caution: cardiac dz risk ( ibuprofen )
- caution: cardiovascular dz ( phenylephrine; ibuprofen )
- caution: CHF ( ibuprofen )
- caution: coagulation disorder ( ibuprofen )
- caution: debilitated pts ( ibuprofen )
- caution: dehydration ( ibuprofen )
- caution: diabetes mellitus ( phenylephrine )
- caution: elderly pts ( ibuprofen )
- caution: female pts trying to conceive ( ibuprofen )
- caution: fluid retention ( ibuprofen )
- caution: glaucoma, angle-closure ( phenylephrine )
- caution: hepatic impairment ( ibuprofen )
- caution: HTN ( ibuprofen; phenylephrine )
- caution: hyperthyroidism ( phenylephrine )
- caution: hypovolemia ( ibuprofen )
- caution: PKU (phenylalanine-containing form) ( phenylephrine )
- caution: pregnancy 2nd trimester ( phenylephrine )
- caution: pregnancy 3rd trimester ( phenylephrine )
- caution: pregnancy at <30 wk gestation ( ibuprofen )
- caution: prolonged use ( ibuprofen )
- caution: prostatic hypertrophy ( phenylephrine )
- caution: pts <6 yo ( phenylephrine )
- caution: renal impairment ( ibuprofen )
- caution: smokers ( ibuprofen )
Drug Interactions .
Overview
ibuprofen
NSAID
- OAT1 inhibitor
- OAT3 inhibitor
- alters gallbladder contraction/motility
- antiplatelet effects
- bioavailability increased by hydroxypropyl betadex
- decreases renal perfusion/fxn
- GI mucosal injury/bleeding risk
- hyperkalemia
- hypertensive effects
- hyponatremia
- lowers seizure threshold
- thrombogenic effects
phenylephrine
alpha-1 agonist
- hyperglycemic effects
- hypertensive effects
- interferes w/ radiolabeled norepinephrine analog effect
- tachycardia
- add MAO inhibitor to Interaction Check if recent (14 days) use
Contraindicated
- dihydroergotamine
- isocarboxazid
- ketorolac
- tranylcypromine
Avoid/Use Alternative
- albuterol
- aspirin
- clofarabine
- cocaine
- diclofenac topical
- dronabinol
- enoxaparin
- ephedra
- etodolac
- fenoprofen
- fondaparinux
- furosemide
- ibuprofen lysine
- iobenguane I 131
- ketoprofen
- lisinopril
- magnesium salicylate
- mefenamic acid
- meloxicam
- methyl salicylate topical
- nabumetone
- naproxen
- ozanimod
- phenylephrine
- piroxicam
- procarbazine
- pseudoephedrine
- safinamide
- salsalate
- selegiline
- tacrolimus
- vaccinia immune globulin
- valsartan
- yohimbe
Monitor/Modify Tx
- abiraterone acetate
- abrocitinib
- acalabrutinib
- acarbose
- acebutolol
- acetaminophen
- acyclovir
- adefovir dipivoxil
- ado-trastuzumab emtansine
- afatinib
- aflibercept
- albuterol inhaled
- aldesleukin
- alendronate
- aliskiren
- almotriptan
- alogliptin
- alteplase
- amikacin inhaled
- amiloride
- aminocaproic acid
- amitriptyline
- amlodipine
- amphetamine
- amphotericin
- anagrelide
- angiotensin II
- anti-inhibitor coagulant complex
- antihemophilic factor (factor VIII)/von Willebrand factor complex
- antithrombin
- apixaban
- arformoterol inhaled
- argatroban
- armodafinil
- asciminib
- asparaginase
- atenolol
- atidarsagene autotemcel
- atomoxetine
- atropine ophthalmic
- auranofin
- avapritinib
- avatrombopag
- axitinib
- azilsartan medoxomil
- balsalazide
- bazedoxifene
- benzphetamine
- betamethasone
- betaxolol
- bevacizumab
- binimetinib
- bismuth subsalicylate
- bisoprolol
- bivalirudin
- botulism immune globulin
- brigatinib
- brolucizumab
- bromelain
- bromfenac ophthalmic
- budesonide
- bupropion
- C1 esterase inhibitor
- cabazitaxel
- cabozantinib
- caffeine
- caffeine citrate
- calaspargase
- canagliflozin
- candesartan cilexetil
- cangrelor
- cannabis
- capecitabine
- caplacizumab
- captopril
- carboplatin
- carfilzomib
- chlorothiazide
- chlorthalidone
- chorionic gonadotropin
- cidofovir
- cilostazol
- cinacalcet
- cisplatin
- citalopram
- cladribine oral
- clevidipine
- clindamycin
- clomipramine
- clonidine
- clopidogrel
- colesevelam
- colistimethate
- collagenase clostridium histolyticum
- copanlisib
- corticotropin
- cortisone
- creatine
- cyclophosphamide
- cyclosporine
- cytomegalovirus immune globulin
- dabigatran
- dalteparin
- danazol
- danshen
- dapagliflozin
- daprodustat
- darbepoetin alfa
- dasatinib
- decitabine
- deferasirox
- deferoxamine
- defibrotide
- deflazacort
- desipramine
- desmopressin
- desvenlafaxine
- dexamethasone
- dexmethylphenidate
- dextroamphetamine
- diclofenac ophthalmic
- diethylpropion
- digoxin
- diltiazem
- dimethyl fumarate
- diosmin
- dipyridamole
- diroximel fumarate
- dobutamine
- donepezil
- dopamine
- doxapram
- doxazosin
- doxepin
- drospirenone (contraceptive)
- drospirenone (hormone replacement)
- droxidopa
- dulaglutide
- duloxetine
- edoxaban
- eletriptan
- eltrombopag
- empagliflozin
- enalapril
- enalaprilat
- encorafenib
- enzalutamide
- ephedrine injection
- ephedrine oral
- epinephrine
- epirubicin
- eplerenone
- epoetin alfa
- epoprostenol
- eptifibatide
- erenumab
- ergotamine
- erlotinib
- ertugliflozin
- escitalopram
- esketamine
- esmolol
- estetrol (contraceptive)
- estradiol (contraceptive)
- etelcalcetide
- ethacrynic acid
- ethanol
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- etrasimod
- evening primrose oil
- exenatide
- faricimab
- fedratinib
- felodipine
- fenfluramine
- fenoldopam
- fenugreek
- finerenone
- fingolimod
- flucytosine
- fludrocortisone
- fluoxetine
- flurbiprofen ophthalmic
- fluvoxamine
- follitropin
- formoterol inhaled
- foscarnet
- fosinopril
- fostamatinib
- frovatriptan
- fruquintinib
- galantamine
- ganciclovir
- garlic
- gefitinib
- gemtuzumab ozogamicin
- gentamicin
- ginkgo
- glimepiride
- glipizide
- glyburide
- guanfacine
- heparin
- hepatitis B immune globulin
- hoodia
- hydralazine
- hydrochlorothiazide
- hydrocortisone
- ibandronate
- ibrutinib
- icosapent ethyl
- ifosfamide
- iloprost inhaled
- imatinib
- immune globulin
- indapamide
- inotersen
- insulin
- iohexol
- iopamidol
- irbesartan
- isoproterenol
- isradipine
- ketamine
- ketorolac ophthalmic
- krill oil
- labetalol
- lanreotide
- leflunomide
- lenalidomide
- lenvatinib
- levalbuterol inhaled
- levomilnacipran
- levonordefrin
- levothyroxine
- licorice
- lifileucel
- linagliptin
- liothyronine
- liraglutide
- lisdexamfetamine
- lithium
- lorlatinib
- losartan
- lumacaftor/ivacaftor
- luspatercept
- lusutrombopag
- lutetium Lu 177 vipivotide tetraxetan
- magnesium citrate
- mesalamine
- mesalamine rectal
- metformin
- methamphetamine
- methoxy polyethylene glycol-epoetin beta
- methyldopa
- methylergonovine
- methylphenidate
- methylprednisolone
- metoclopramide
- metolazone
- metoprolol
- milnacipran
- minoxidil
- mirabegron
- mitomycin
- mitotane
- modafinil
- moexipril
- momelotinib
- monomethyl fumarate
- nadolol
- naphazoline ophthalmic
- naratriptan
- nateglinide
- nattokinase
- naxitamab
- nebivolol
- necitumumab
- neomycin
- nepafenac ophthalmic
- niacin (vitamin B3)
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nintedanib
- niraparib
- nisoldipine
- norepinephrine
- norgestrel (contraceptive)
- nortriptyline
- nusinersen
- olmesartan medoxomil
- olodaterol inhaled
- olsalazine
- omega-3-acid
- osilodrostat
- oxaliplatin
- oxymetazoline nasal
- oxymetazoline ophthalmic
- oxymetazoline topical
- oxytocin
- pacritinib
- pamidronate
- paromomycin
- paroxetine
- pazopanib
- pegaspargase
- penicillamine
- penicillin G
- pentamidine
- pentosan polysulfate sodium
- pentostatin
- pentoxifylline
- perindopril
- pexidartinib
- phendimetrazine
- phenoxybenzamine
- phentermine
- phentolamine
- phenylephrine injection
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine rectal
- pindolol
- pioglitazone
- piperacillin
- pirtobrutinib
- plasminogen, human
- plazomicin
- polyethylene glycol
- polyethylene glycol/electrolytes
- polymyxin B
- pomalidomide
- ponatinib
- ponesimod
- porfimer
- potassium acid phosphate
- potassium bicarbonate
- potassium citrate
- potassium iodide
- potassium phosphate
- pralatrexate
- pralsetinib
- pramlintide
- prasugrel
- prazosin
- prednisolone
- prednisone
- propranolol
- prothrombin complex concentrate (human)
- protriptyline
- pyridostigmine
- quetiapine
- quinapril
- ramipril
- ramucirumab
- ranibizumab
- regorafenib
- repaglinide
- reteplase
- Rho(D) immune globulin
- ripretinib
- risedronate
- ritlecitinib
- rituximab
- rivaroxaban
- rivastigmine
- rizatriptan
- romiplostim
- ropeginterferon alfa-2b
- ropinirole
- rosiglitazone
- rotigotine transdermal
- salmeterol inhaled
- saw palmetto
- saxagliptin
- selpercatinib
- selumetinib
- semaglutide
- sertraline
- sincalide
- siponimod
- sirolimus
- sirolimus albumin-bound
- sitagliptin
- sodium phosphate (bowel prep)
- solriamfetol
- sorafenib
- sotatercept
- sparsentan
- spironolactone
- streptomycin
- streptozocin
- sulfate bowel prep
- sumatriptan
- sunitinib
- tagraxofusp
- telavancin
- telmisartan
- temsirolimus
- tenecteplase
- tenofovir alafenamide
- terazosin
- terbutaline
- teriflunomide
- testosterone
- thalidomide
- thyroid
- ticagrelor
- timolol
- tiopronin
- tipranavir
- tirofiban
- tirzepatide
- tisotumab vedotin
- tivozanib
- tobramycin
- tobramycin inhaled
- tocilizumab
- tolvaptan
- torsemide
- tovorafenib
- trametinib
- trandolapril
- trazodone
- treprostinil
- triamcinolone
- triamterene
- trimethoprim
- trimipramine
- upadacitinib
- valacyclovir
- valganciclovir
- valoctocogene roxaparvovec
- valproic acid
- vamorolone
- vancomycin
- vandetanib
- vasopressin
- venlafaxine
- verapamil
- vilanterol inhaled
- vilazodone
- viloxazine
- vinpocetine
- voclosporin
- von Willebrand factor
- vorapaxar
- voriconazole
- vorinostat
- vortioxetine
- warfarin
- zanubrutinib
- ziv-aflibercept
- zoledronic acid
- zolmitriptan
- zonisamide
Caution Advised
- carbamazepine
- ciprofloxacin
- delafloxacin
- emtricitabine
- levofloxacin
- moxifloxacin
- ofloxacin
Adverse Reactions .
Serious Reactions
- anaphylaxis ( ibuprofen )
- aseptic meningitis ( ibuprofen )
- blood dyscrasias ( ibuprofen )
- CHF ( ibuprofen )
- arrhythmia ( phenylephrine )
- CHF exacerbation ( ibuprofen )
- drug rxn w/ eosinophilia and systemic sx ( ibuprofen )
- exfoliative dermatitis ( ibuprofen )
- GI bleeding ( ibuprofen )
- GI perforation ( ibuprofen )
- GI ulcer ( ibuprofen )
- HTN ( phenylephrine ; ibuprofen )
- hepatotoxicity ( ibuprofen )
- hyperkalemia ( ibuprofen )
- hypersensitivity rxn ( ibuprofen )
- medication overuse headache (acute migraine or headache use >10 days/mo) ( ibuprofen )
- MI ( ibuprofen )
- nephrotoxicity ( ibuprofen )
- prolonged bleeding time ( ibuprofen )
- renal papillary necrosis ( ibuprofen )
- Stevens-Johnson syndrome ( ibuprofen )
- stroke ( ibuprofen )
- thrombocytopenia ( ibuprofen )
- thromboembolism ( ibuprofen )
- toxic epidermal necrolysis ( ibuprofen )
Common Reactions
- abdominal pain ( ibuprofen )
- ALT or AST elevated ( ibuprofen )
- anxiety ( phenylephrine )
- CNS stimulation ( phenylephrine )
- appetite decr. ( ibuprofen )
- constipation ( ibuprofen )
- dizziness ( phenylephrine ; ibuprofen )
- delayed ovulation ( ibuprofen )
- diarrhea ( ibuprofen )
- dry mouth ( phenylephrine )
- drowsiness ( ibuprofen )
- headache ( phenylephrine ; ibuprofen )
- dyspepsia ( ibuprofen )
- ecchymosis ( ibuprofen )
- nausea ( phenylephrine ; ibuprofen )
- insomnia ( phenylephrine )
- flatulence ( ibuprofen )
- fluid retention ( ibuprofen )
- Hgb decr. ( ibuprofen )
- nervousness ( ibuprofen )
- photosensitivity ( ibuprofen )
- pruritus ( ibuprofen )
- rash ( ibuprofen )
- renal impairment ( ibuprofen )
- tinnitus ( ibuprofen )
- visual disturbance ( ibuprofen )
- vomiting ( ibuprofen )
Pregnancy/Lactation .
Pregnancy
Clinical Summary
ibuprofen: weigh risk/benefit if <30 wk gestation, esp. at 20-29 wk gestation, avoid use starting at 30 wk gestation; if must use at 20-29 wk gestation, limit dose and duration, and consider monitoring amniotic fluid if use >48h; risk of embryo-fetal toxicity and death low in 1st trimester based on conflicting human data; risk of fetal harm, incl. renal dysfxn and oligohydramnios, starting at 20 wk gestation and premature ductus arteriosus closure, starting at 30 wk gestation, based on human data w/ NSAID class and drug's mechanism of action
phenylephrine: avoid use in 1st trimester, weigh risk/benefit in 2nd and 3rd trimesters; possible risk of teratogenicity based on conflicting human data; risk of vasoconstriction based on animal data and drug's mechanism of action
Individuals of Reproductive Potential
ibuprofen: weigh risk/benefit in female pts, esp. if long-term use; NSAIDs may delay ovulation during tx based on limited human or animal data and drug's mechanism of action
Lactation
Clinical Summary
ibuprofen: may use while breastfeeding; NSAID of choice for analgesic use while breastfeeding; no known risk of infant harm or adverse effects on milk production based on human data
phenylephrine: weigh risk/benefit while breastfeeding; no human data available, though risk of infant harm not expected based on drug properties; no human data available to assess effects on milk production
Pharmacology .
Metabolism: combination; see individual drugs
Excretion: combination; see individual drugs
Subclass: Analgesic/Decongestant Combos
Mechanism of Action: combination; see individual drugs
Alternatives .
Search for Alternative Products by:
- Other OTCs w/ Same Active Ingredient(s)
- Sudafed PE Head Congestion + Pain: oral tablet
- Same Subclass
- Analgesic/Decongestant Combos
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