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Nesina
alogliptin
Adult Dosing .
Dosage forms: TAB: 6.25 mg, 12.5 mg, 25 mg
diabetes mellitus, type 2
- [25 mg PO qd]
- Info: do not cut/crush/chew tab
renal dosing
- [adjust dose amount]
- CrCl 30-59: 12.5 mg qd; CrCl <30: 6.25 mg qd
- HD: 6.25 mg qd; no supplement after dialysis; PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- diabetes mellitus, type 1
- heart failure
- caution: heart failure risk
- caution: renal impairment
- caution: LFTs elevated
Drug Interactions .
Overview
alogliptin
DPP-4 inhibitor
- antidiabetic agent
- cardiotoxic effects
Avoid/Use Alternative
- epirubicin
- idarubicin
- linagliptin
- saxagliptin
- sitagliptin
Monitor/Modify Tx
- acebutolol
- adalimumab
- ado-trastuzumab emtansine
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- diflorasone topical
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- eleuthero
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- estradiol (hormone replacement)
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- estrogens, esterified (hormone replacement)
- ethacrynic acid
- ethanol
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- fluoxetine
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- garlic
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- glyburide
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- norgestrel (contraceptive)
- octreotide
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- paliperidone
- pasireotide
- pegaspargase
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- pertuzumab
- phenelzine
- phenylephrine
- phenytoin
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- ponatinib
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- ribose
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- segesterone (contraceptive)
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- somapacitan
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- sotalol
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- thyroid
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- torsemide
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- tranylcypromine
- trastuzumab
- triamcinolone
- triamcinolone topical
- triamterene
- triptorelin
- vamorolone
- vorinostat
- ziprasidone
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- anaphylaxis
- Stevens-Johnson syndrome
- hepatic failure
- tubulointerstitial nephritis
- heart failure
- pancreatitis
- hypoglycemia
- arthralgia, severe
- bullous pemphigoid
- rhabdomyolysis
Common Reactions
- hypoglycemia
- nasopharyngitis
- URI
- headache
- renal impairment
- ALT incr.
Safety/Monitoring .
Monitoring Parameters
Cr at baseline, then periodically; LFTs at baseline, then as clinically indicated
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at 149x and 180x recommended human dose
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: limited; CYP450: none
Excretion: urine 76% (60-71% unchanged), feces 13%; Half-life: 21h
Subclass: Diabetes: DPP-4 Inhibitors
Mechanism of Action
inhibits dipeptidyl peptidase-4, slowing incretin metabolism, increasing insulin synthesis/release, decreasing glucagon levels
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: Takeda Pharmaceuticals North America, Inc.
DEA/FDA: Rx
Approximate Retail Price
from http://www.goodrx.com/nesina
oral tablet:
- 6.25 mg (30 ea): $427.00
- 12.5 mg (15 ea): $218.00
- 25 mg (30 ea): $427.00
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