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eszopiclone
generic
Black Box Warnings .
Complex Sleep Behaviors
complex sleep behaviors may occur, incl. sleep-walking, sleep-driving, and engaging in other activities while not fully awake; may result in serious injuries, incl. death; D/C immediately if pt experiences a complex sleep behavior
Adult Dosing .
Dosage forms: TAB: 1 mg, 2 mg, 3 mg
insomnia
- [1-3 mg PO qhs]
- Start: 1 mg PO qhs; Max: 3 mg/day; Info: for sleep onset and/or maintenance; use lowest effective dose; give >7h before planned awakening; max 2 mg/day in elderly or debilitated pts; avoid admin. w/ high fat meal; taper dose gradually to D/C if prolonged use
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- severe impairment: max 2 mg/day
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- complex sleep behavior hx
- alcohol use, concurrent
- abrupt withdrawal (prolonged use)
- caution: CNS depressant use, concurrent
- caution: alcohol abuse hx
- caution: drug abuse hx
- caution: depression
- caution: psychiatric disorder
- caution: respiratory fxn, impaired
- caution: hepatic impairment, severe
- caution: elderly pts
- caution: debilitated pts
Drug Interactions .
Overview
eszopiclone
nonbenzodiazepine hypnotic
- CYP3A4 substrate
- CNS depression
Avoid/Use Alternative
- butalbital
- codeine
- daridorexant
- estazolam
- ethanol
- hydrocodone
- isocarboxazid
- kratom
- lemborexant
- metaxalone
- metoclopramide
- oliceridine
- oxybate
- phenelzine
- promethazine
- quazepam
- ropeginterferon alfa-2b
- suvorexant
- tasimelteon
- temazepam
- thalidomide
- tranylcypromine
- triazolam
- trimethobenzamide
- zaleplon
- zolpidem
Monitor/Modify Tx
- 5-HTP
- adagrasib
- aldesleukin
- alfentanil
- allopurinol
- almotriptan
- alprazolam
- amantadine
- amitriptyline
- amoxapine
- apomorphine
- apraclonidine ophthalmic
- aripiprazole
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- asenapine
- atazanavir
- baclofen
- baclofen intrathecal
- berotralstat
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- buprenorphine
- buspirone
- butorphanol
- cannabidiol
- cannabis
- carbamazepine
- carbinoxamine
- cariprazine
- carisoprodol
- cenobamate
- ceritinib
- cetirizine
- chamomile, German
- chloramphenicol
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- citalopram
- clarithromycin
- clemastine
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- cyclobenzaprine
- cyproheptadine
- dantrolene
- darifenacin
- desflurane
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexchlorpheniramine
- dexmedetomidine
- dexmedetomidine injection
- diazepam
- dichlorphenamide
- difelikefalin
- difenoxin
- dihydrocodeine
- dimenhydrinate
- diphenhydramine
- diphenoxylate
- domperidone
- doxepin
- doxepin topical
- dronabinol
- droperidol
- duloxetine
- efavirenz
- eletriptan
- entrectinib
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine acetate
- ethanol (in some formulations)
- ethosuximide
- etomidate
- felbamate
- fenfluramine
- fentanyl
- fesoterodine
- flibanserin
- fluoxetine
- fluphenazine
- fluvoxamine
- fosphenytoin
- frovatriptan
- gabapentin
- gabapentin enacarbil
- ganaxolone
- glofitamab
- glycopyrrolate
- guanfacine
- haloperidol
- hydromorphone
- hydroxyzine
- hyoscyamine
- idelalisib
- ifosfamide
- iloperidone
- imipramine
- isoflurane
- itraconazole
- ketamine
- ketoconazole
- lacosamide
- lamotrigine
- lasmiditan
- levetiracetam
- levocetirizine
- levodopa
- levoketoconazole
- levomilnacipran
- levorphanol
- lofexidine
- lonafarnib
- lopinavir/ritonavir
- lorazepam
- loxapine
- lumateperone
- lurasidone
- meclizine
- melatonin
- meperidine
- meprobamate
- methadone
- methohexital
- methsuximide
- methyldopa
- metyrapone
- metyrosine
- mifepristone
- milnacipran
- mirtazapine
- mitotane
- molindone
- morphine
- mosunetuzumab
- mycophenolate mofetil
- nalbuphine
- naltrexone
- naratriptan
- nefazodone
- nelarabine
- nelfinavir
- nortriptyline
- olanzapine
- opicapone
- opium
- orphenadrine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- paliperidone
- paroxetine
- passion flower
- pentazocine
- pentobarbital
- perampanel
- perphenazine
- pheniramine
- phenobarbital
- phenytoin
- pimozide
- posaconazole
- pramipexole
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- propofol
- protriptyline
- pyrilamine
- quetiapine
- rasagiline
- remifentanil
- remimazolam
- repotrectinib
- ribociclib
- risperidone
- rizatriptan
- ropinirole
- rotigotine transdermal
- rufinamide
- safinamide
- saquinavir
- scopolamine
- selegiline
- selegiline transdermal
- selinexor
- sertraline
- sevoflurane
- solifenacin
- stiripentol
- sufentanil
- sumatriptan
- tapentadol
- tetrabenazine
- thioridazine
- thiothixene
- tipranavir
- tizanidine
- tolcapone
- tolterodine
- topiramate
- tramadol
- trazodone
- trifluoperazine
- trihexyphenidyl
- trimipramine
- triprolidine
- trospium
- tucatinib
- valbenazine
- valerian
- valproic acid
- venlafaxine
- vigabatrin
- vilazodone
- viloxazine
- voriconazole
- ziconotide
- ziprasidone
- zolmitriptan
- zonisamide
Caution Advised
- apalutamide
- bosentan
- dabrafenib
- encorafenib
- enzalutamide
- etravirine
- ivosidenib
- lorlatinib
- lumacaftor/ivacaftor
- mavacamten
- mitapivat
- modafinil
- nafcillin
- pexidartinib
- rifabutin
- rifampin
- rifapentine
- sotorasib
- St. John's wort
Adverse Reactions .
Serious Reactions
- complex sleep-related behavior
- impaired mental alertness, next-day
- depression exacerbation
- suicidality
- hallucinations
- aggressive behavior
- amnesia
- hypersensitivity rxn
- anaphylactoid rxn
- anaphylaxis
- angioedema
- abuse
- dependency
- withdrawal sx if abrupt D/C (prolonged use)
Common Reactions
- unpleasant taste
- headache
- somnolence
- infection
- xerostomia
- dizziness
- nausea
- dyspepsia
- pain
- diarrhea
- rash
- viral infection
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no known risk of teratogenicity based on limited human and animal data; risk of embryo-fetal toxicity based on conflicting animal data at >300x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: generic
DEA/FDA: Schedule IV
Approximate Retail Price
from http://www.goodrx.com/eszopiclone
oral tablet:
- 1 mg (30 ea): $20.00
- 2 mg (30 ea): $17.00
- 3 mg (30 ea): $19.00
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