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Dificid
fidaxomicin
Adult Dosing .
Dosage forms: TAB: 200 mg; SUSP: 40 mg per mL
C. difficile infection
- [200 mg PO bid x10 days]
- Info: 1st-line agent for non-fulminant dz
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: TAB: 200 mg; SUSP: 40 mg per mL
C. difficile infection
- [6 mo and older, 4-6.9 kg]
- Dose: 80 mg susp PO bid x10 days
- [6 mo and older, 7-8.9 kg]
- Dose: 120 mg susp PO bid x10 days
- [6 mo and older, 9-12.4 kg]
- Dose: 160 mg susp PO bid x10 days
- [6 mo and older, >12.5 kg]
- Dose: 200 mg PO bid x10 days
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
fidaxomicin
macrolide
- alters GI flora
Avoid/Use Alternative
- fecal microbiota, live
- methotrexate
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- GI hemorrhage
- neutropenia
- anemia
Common Reactions
- nausea
- vomiting
- abdominal pain
- GI hemorrhage
- constipation (peds pts)
- rash (peds pts)
- LFTs incr. (peds pts)
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on minimal systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on minimal maternal systemic absorption
Pharmacology .
Metabolism: GI tract; CYP450: none; Info: active metabolite; P-gp substrate; minimal systemic absorption
Excretion: feces >92%, urine <1%; Half-life: 11.2-11.7h
Subclass: Clostridioides difficile ; Macrolides
Mechanism of Action
binds to RNA polymerases, inhibiting RNA synthesis
Formulary .
No Formulary Selected
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