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Vicodin
hydrocodone/ acetaminophen
Black Box Warnings .
Brand Discontinued in US
select or search generic name for alternatives
Contraindications / Cautions .
- Brand Discontinued in US
Drug Interactions .
Overview
acetaminophen
centrally-acting analgesic/antipyretic
- CYP2E1 substrate
- UGT1A1 substrate
- affected by altered gastrointestinal motility
- methemoglobinemia
hydrocodone
opioid
- CYP2D6 substrate
- CYP3A4 substrate
- antidiuretic hormone effects
- CNS depression
- decreases gastrointestinal motility
- hyponatremia
- hypotensive effects
- lowers seizure threshold
- opioid agonist
- potentiates neuromuscular blockade
- prolongs QT interval (conditional)
- serotonergic effects
- urinary retention
- benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated
- consider prescribing naloxone, esp. w/ concomitant CNS depressant use
- add MAO inhibitor to Interaction Check if recent (14 days) use
Contraindicated
- lidocaine topical
- naltrexone
- pimozide
- potassium chloride
- potassium citrate
- prilocaine topical
- safinamide
- samidorphan
- thioridazine
Avoid/Use Alternative
- 5-HTP
- adagrasib
- aldesleukin
- alfentanil
- allopurinol
- almotriptan
- alprazolam
- amantadine
- amifampridine
- amiodarone
- amitriptyline
- amlodipine
- amoxapine
- amphetamine
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- aripiprazole
- aripiprazole lauroxil
- arsenic trioxide
- asciminib
- asenapine
- atazanavir
- atorvastatin
- avacopan
- baclofen
- baclofen intrathecal
- bedaquiline
- belumosudil
- berberine
- berotralstat
- bicalutamide
- bosentan
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- buprenorphine
- bupropion
- buspirone
- butalbital
- butorphanol
- cannabidiol
- cannabis
- capivasertib
- carbamazepine
- carbinoxamine
- cariprazine
- carisoprodol
- cenobamate
- ceritinib
- cetirizine
- chamomile, German
- chloramphenicol
- chlordiazepoxide
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- cilostazol
- cimetidine
- ciprofloxacin
- cisapride
- citalopram
- clarithromycin
- clemastine
- clobazam
- clofazimine
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clotrimazole oropharyngeal
- clozapine
- cobicistat
- cocaine
- codeine
- conivaptan
- cranberry
- crizotinib
- cyclobenzaprine
- cyclosporine
- cyproheptadine
- dabrafenib
- danazol
- dantrolene
- daridorexant
- darifenacin
- darunavir
- desflurane
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexchlorpheniramine
- dexmedetomidine
- dexmedetomidine injection
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- diazepam
- dichlorphenamide
- difelikefalin
- difenoxin
- dihydrocodeine
- dihydroergotamine
- diltiazem
- dimenhydrinate
- diosmin
- diphenhydramine
- diphenoxylate
- domperidone
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- duloxetine
- duvelisib
- efavirenz
- eletriptan
- eluxadoline
- encorafenib
- entacapone
- entrectinib
- enzalutamide
- ephedra
- ergotamine
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine acetate
- estazolam
- eszopiclone
- ethanol
- ethanol (in some formulations)
- ethinyl estradiol (contraceptive)
- ethosuximide
- etomidate
- etravirine
- everolimus
- fedratinib
- felbamate
- fenfluramine
- fentanyl
- fesoterodine
- fexinidazole
- flibanserin
- fluconazole
- fluoxetine
- fluphenazine
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosphenytoin
- fostamatinib
- frovatriptan
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gepirone
- ginkgo
- givosiran
- glecaprevir
- glofitamab
- glycopyrrolate
- goldenseal
- granisetron
- grapefruit
- grazoprevir
- guanfacine
- haloperidol
- hydrocodone
- hydromorphone
- hydroxychloroquine
- hydroxyzine
- hyoscyamine
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imipramine
- iohexol
- isavuconazonium
- isocarboxazid
- isoflurane
- isoniazid
- istradefylline
- itraconazole
- ivacaftor
- ivosidenib
- kava
- ketamine
- ketoconazole
- kratom
- lacosamide
- lamotrigine
- lapatinib
- larotrectinib
- lasmiditan
- lefamulin
- lemborexant
- lenacapavir
- letermovir
- levetiracetam
- levocetirizine
- levodopa
- levoketoconazole
- levomilnacipran
- levorphanol
- linezolid
- lisdexamfetamine
- lithium
- lofexidine
- lomitapide
- lonafarnib
- lopinavir/ritonavir
- lorazepam
- lorlatinib
- lovastatin
- loxapine
- lumacaftor/ivacaftor
- lumateperone
- lurasidone
- maribavir
- mavacamten
- mavorixafor
- meclizine
- melatonin
- meperidine
- meprobamate
- metaxalone
- methadone
- methamphetamine
- methocarbamol
- methohexital
- methsuximide
- methyldopa
- methylene blue injection
- methylene blue oral
- methylergonovine
- methylphenidate
- metoclopramide
- metyrapone
- metyrosine
- midazolam
- mifepristone
- milnacipran
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- molindone
- morphine
- mosunetuzumab
- mycophenolate mofetil
- nafcillin
- nalbuphine
- naratriptan
- nefazodone
- nelarabine
- nelfinavir
- netupitant
- nicardipine
- nilotinib
- nirogacestat
- nortriptyline
- olanzapine
- oliceridine
- ondansetron
- opicapone
- opium
- orphenadrine
- osilodrostat
- oxazepam
- oxcarbazepine
- oxybate
- oxybutynin
- oxycodone
- oxymorphone
- ozanimod
- pacritinib
- palbociclib
- paliperidone
- palonosetron
- paroxetine
- passion flower
- pazopanib
- pentazocine
- pentobarbital
- peppermint
- perampanel
- perphenazine
- pexidartinib
- phenelzine
- pheniramine
- phenobarbital
- phenytoin
- pibrentasvir
- pirtobrutinib
- posaconazole
- pramipexole
- pramlintide
- prasugrel
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- propofol
- protriptyline
- quazepam
- quercetin
- quinidine (CYP2D6 inhibitor)
- ranolazine
- rasagiline
- remimazolam
- repotrectinib
- rifabutin
- rifampin
- ritlecitinib
- rizatriptan
- rucaparib
- saquinavir
- scopolamine
- selegiline
- selegiline transdermal
- sertraline
- sevoflurane
- sotorasib
- stiripentol
- sufentanil
- sumatriptan
- tapentadol
- tasimelteon
- tetrabenazine
- thalidomide
- tiagabine
- tipranavir
- tolcapone
- tolvaptan
- topiramate
- tramadol
- tranylcypromine
- trazodone
- trifluoperazine
- trihexyphenidyl
- trimethobenzamide
- trimipramine
- triprolidine
- tucatinib
- valerian
- valproic acid
- venlafaxine
- verapamil
- voriconazole
- vortioxetine
- voxelotor
- yohimbe
- zaleplon
- zileuton
- zolmitriptan
- zolpidem
- zuranolone
Monitor/Modify Tx
- acetaminophen
- alfuzosin
- aliskiren
- amiloride
- anagrelide
- aripiprazole bimonthly injection
- articaine
- atenolol
- atracurium
- avanafil
- azilsartan medoxomil
- azithromycin
- benazepril
- betaxolol
- bethanechol
- bexagliflozin
- bisoprolol
- bortezomib
- brexucabtagene autoleucel
- bumetanide
- bupivacaine
- bupivacaine liposomal
- cabergoline
- canagliflozin
- candesartan cilexetil
- captopril
- carteolol ophthalmic
- carvedilol
- chloroprocaine
- chloroquine
- chlorothiazide
- chlorthalidone
- cisatracurium
- clevidipine
- clofarabine
- coenzyme Q-10
- dapagliflozin
- desmopressin
- diclofenac
- diflunisal
- dinutuximab
- disopyramide
- dofetilide
- donepezil
- doxazosin
- empagliflozin
- enalapril
- enalaprilat
- epirubicin
- epoprostenol
- eribulin
- ertugliflozin
- ethacrynic acid
- etodolac
- exenatide
- felodipine
- fenoldopam
- fenoprofen
- ferumoxytol
- flecainide
- fluorouracil
- flurbiprofen
- fosinopril
- furosemide
- garlic
- gemfibrozil
- gilteritinib
- glasdegib
- goserelin
- histrelin
- hydralazine
- hydrochlorothiazide
- ibuprofen
- ibutilide
- iloprost
- iloprost inhaled
- indapamide
- inotuzumab ozogamicin
- iobenguane I 131
- irbesartan
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- ketoprofen
- labetalol
- lenvatinib
- leuprolide
- levobunolol ophthalmic
- levofloxacin
- lidocaine
- lisinopril
- losartan
- lubiprostone
- magnesium salicylate
- maraviroc
- meclofenamate
- mefenamic acid
- meloxicam
- metoprolol
- milrinone
- minoxidil
- moxifloxacin
- nadolol
- naproxen
- nattokinase
- nebivolol
- niacin (vitamin B3)
- nifedipine
- nimodipine
- nitisinone
- nitric oxide
- nitrite
- nitroglycerin
- nitroprusside
- olmesartan medoxomil
- osimertinib
- oxaprozin
- pamabrom
- panobinostat
- pasireotide
- pegvisomant
- pentamidine
- perindopril
- phenoxybenzamine
- phentolamine
- pindolol
- piroxicam
- prazosin
- probenecid
- procainamide
- propafenone
- propranolol
- quinapril
- quinidine (antiarrhythmic)
- quinine
- ramipril
- regorafenib
- riociguat
- romidepsin
- ropivacaine
- sacubitril
- salsalate
- sildenafil
- silodosin
- sodium ferric gluconate complex
- sorafenib
- sotagliflozin
- sparsentan
- sulindac
- tadalafil
- tagraxofusp
- tamsulosin
- taurine
- telavancin
- telmisartan
- terazosin
- timolol
- timolol ophthalmic
- tolmetin
- torsemide
- trandolapril
- treprostinil
- triamterene
- triclabendazole
- trifluridine
- triptorelin
- valsartan
- vardenafil
- vasopressin
- vemurafenib
- vosoritide
- warfarin
Caution Advised
- acetazolamide
- aclidinium inhaled
- alosetron
- atropine
- barium
- belladonna alkaloids
- benzocaine topical
- benztropine
- botulinum toxin
- busulfan
- butamben
- chlorambucil
- clidinium
- dacomitinib
- dapsone
- dapsone topical
- dicyclomine
- erenumab
- flavoxate
- glutathione
- glycopyrrolate inhaled
- glycopyrronium topical
- homatropine
- ipratropium inhaled
- lactulose
- lindane topical
- loperamide
- magnesium citrate
- methscopolamine
- mexiletine
- phenazopyridine
- polyethylene glycol
- polyethylene glycol/electrolytes
- potassium acid phosphate
- potassium gluconate
- potassium phosphate
- procaine
- pyridostigmine
- sodium phosphate (bowel prep)
- sodium picosulfate
- succinylcholine
- sulfate bowel prep
- tafenoquine
- terbinafine
- tetracaine
- tiotropium inhaled
- tirzepatide
- vibegron
Adverse Reactions .
Serious Reactions
- Brand Discontinued in US
Common Reactions
- Brand Discontinued in US
Safety/Monitoring .
Brand Discontinued in US
Look/Sound-Alike Drug Names
Vicodin confused with: Hycodan; Percodan; Uridon; Valium; Vicodin ES; Vioxx; Visicol; Vytorin
HYDROcodone/acetaminophen confused with: acetaminophen/codeine; oxyCODONE/acetaminophen; HYDROcodone/guaiFENesin; HYDROcodone/homatropine; HYDROcodone/ibuprofen; HYDROmorphone
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: AbbVie Inc.
DEA/FDA: Discontinued
Approximate Retail Price
This information is currently not available for this drug.
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