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Mitosol
mitomycin ophthalmic
Adult Dosing .
Dosage forms: SOL: 0.2 mg per mL
ab externo glaucoma surgery adjunct
- [apply sponges to surgical site x2min]
- Info: saturate sponges in solution x60sec before application
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- intraocular use
- avoid: breastfeeding during tx and x1wk after admin.
Drug Interactions .
Overview
mitomycin ophthalmic
antimetabolite ophthalmic
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- cataracts
- corneal damage
- scleral damage
- retinal detachment
- vision loss, severe
- ocular hypotony
Common Reactions
- blebitis
- corneal rxn
- endophthalmitis
- hypotony
- choroidal rxn
- iritis
- fibrin rxn
- lenticular changes
- retinal pigment epithelial tear
- vascular rxn
Safety/Monitoring .
Monitoring Parameters
pregnancy test at baseline
Look/Sound-Alike Drug Names
mitoMYcin confused with: mitoXANTRONE
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available, though risk of fetal harm low based on expected limited systemic absorption; risk of teratogenicity based on animal data w/ systemically absorbed mitomycin
Individuals of Reproductive Potential
obtain pregnancy test prior to administration
Lactation
Clinical Summary
avoid breastfeeding during and x1wk after admin; no human data available, though risk of infant harm low based on limited maternal systemic absorption; no human data available to assess effects on milk production
Pharmacology .
Metabolism: liver primarily, other tissues; CYP450: none; Info: minimal to no systemic absorption
Excretion: urine (10% unchanged); Half-life: 25-90 min
Subclass: Antineoplastics, Ophthalmic
Mechanism of Action
inhibits DNA synthesis, prevents scarring of surgical site
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: Mobius Therapeutics LLC
DEA/FDA: Rx
Approximate Retail Price
from http://www.goodrx.com/mitosol
ophthalmic kit:
- 0.2 mg (2 kit, 1 vial): $846.00
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