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Neo-Polycin
bacitracin/ neomycin/ polymyxin B ophthalmic
Adult Dosing .
Dosage forms: OINT: 400 units/3.5 mg/10,000 units per g
ocular infections, superficial bacterial
- [apply 0.5 inch ribbon in eye(s) q3-4h x7-10 days]
Peds Dosing .
- Dosage forms: OINT: 400 units/3.5 mg/10,000 units per g
ocular infections, superficial bacterial (off-label)
- [children]
- Dose: apply 0.5 inch ribbon in eye(s) q3-4h x7-10 days
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
bacitracin ophthalmic
polypeptide antibiotic ophthalmic
-
None
neomycin ophthalmic
aminoglycoside ophthalmic
-
None
polymyxin B ophthalmic
polypeptide antibiotic
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- anaphylaxis
- superinfection (prolonged use)
Common Reactions
- ocular pruritus
- ocular inflammation
- conjunctival erythema
- ocular burning
- ocular stinging
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Look/Sound-Alike Drug Names
bacitracin/neomycin/polymyxin B confused with: neomycin/polymyxin B/gramicidin
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on expected limited systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on minimal to no maternal systemic absorption
Pharmacology .
Metabolism: for bacitracin: none; CYP450: none; Info: minimal systemic absorption; for neomycin: none; CYP450: none; Info: minimal systemic absorption; for polymyxin B: unknown; CYP450: unknown; Info: minimal systemic absorption
Excretion: for bacitracin: unknown; Half-life: unknown; for neomycin: unknown; Half-life: unknown; for polymyxin B: unknown; Half-life: unknown
Subclass: Antibacterials, Ophthalmic
Mechanism of Action
bacitracin inhibits cell wall synthesis (polypeptide); neomycin binds to bacterial 30S ribosomal subunit, inhibiting protein synthesis; polymyxin B increases cell wall permeability (polypeptide)
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: Perrigo
DEA/FDA: Rx
Approximate Retail Price
from http://www.goodrx.com/neo-polycin
ophthalmic ointment:
- 3.5 mg/g/10000 units/g/400 units/g (1 tube, 3.5 g): $23.00
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