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Arzerra
ofatumumab
Black Box Warnings .
HBV Reactivation
can occur, incl. cases resulting in fulminant hepatitis, hepatic failure, and death
Progressive Multifocal Leukoencephalopathy
can occur, incl. fatal PML
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments
CLL, previously untreated
- [1000 mg IV x1 on day 1 of 28-day cycle, starting cycle 2]
- Start: 300 mg IV x1 on day 1, then 1000 mg IV x1 on day 8 of 28-day cycle for cycle 1; Max: 12 cycles; Info: give for at least 3 cycles; use w/ chlorambucil; give HBV prophylaxis before tx start, during tx, and for up to 12mo after D/C in anti-HBc positive pts
CLL, relapsed
- [1000 mg IV x1 on day 1 of 28-day cycle, starting cycle 2]
- Start: 300 mg IV x1 on day 1, then 1000 mg IV x1 on day 8 of 28-day cycle for cycle 1; Max: 6 cycles; Info: use w/ fludarabine and cyclophosphamide; give HBV prophylaxis before tx start, during tx, and for up to 12mo after D/C in anti-HBc positive pts
CLL, maintenance tx
- [1000 mg IV q8wk starting wk 17]
- Start: 300 mg IV x1, then 1wk later 1000 mg IV x1, then 7wk later 1000 mg IV x1; Max: 2y; Info: for pts in CR or PR after at least 2 tx for recurrent dz; give HBV prophylaxis before tx start, during tx, and for up to 12mo after D/C in anti-HBc positive pts
CLL, refractory
- [300 mg IV x1, then 1wk later 2000 mg IV qwk x7 doses, then 4wk later 2000 mg IV q4wk x4 doses]
- Info: give HBV prophylaxis before tx start, during tx, and for up to 12mo after D/C in anti-HBc positive pts
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.