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Lexiscan
regadenoson
Adult Dosing .
Dosage forms: INJ
myocardial perfusion imaging
- [0.4 mg IV x1]
- Info: for pts unable to undergo adequate exercise stress
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- AV block, 2nd-3rd degree (pts w/o pacemaker)
- sinus node dysfxn (pts w/o pacemaker)
- myocardial ischemia s/sx, acute
- avoid: breastfeeding x10h after each dose
- caution: atrial arrhythmia
- caution: valvular heart dz, stenotic
- caution: left main coronary artery stenosis
- caution: carotid artery stenosis w/ cerebrovascular insufficiency
- caution: pericardial effusion
- caution: pericarditis
- caution: autonomic dysfxn
- caution: seizure disorder
- caution: seizure hx
- caution: stroke hx
- caution: stroke risk
- caution: hypovolemia
- caution: HTN
- caution: asthma
- caution: COPD
Drug Interactions .
Overview
regadenoson
adenosine agonist; diagnostic agent
- bradycardia
- delays atrioventricular conduction
- lowers seizure threshold
Avoid/Use Alternative
- aldesleukin
- brigatinib
- clonidine
- etrasimod
- fexinidazole
- fingolimod
- iohexol
- ozanimod
- ponesimod
- siponimod
Monitor/Modify Tx
- acebutolol
- adenosine
- alectinib
- alfentanil
- aminophylline
- apraclonidine ophthalmic
- articaine
- atazanavir
- atenolol
- betaxolol
- betaxolol ophthalmic
- bisoprolol
- bupivacaine
- bupivacaine liposomal
- bupropion
- caffeine
- carbamazepine
- carteolol ophthalmic
- carvedilol
- chloroprocaine
- dexmedetomidine
- dexmedetomidine injection
- digoxin
- dipyridamole
- donepezil
- dulaglutide
- esmolol
- guanfacine
- iopamidol
- ivabradine
- labetalol
- lacosamide
- lasmiditan
- levobunolol ophthalmic
- lidocaine
- lopinavir/ritonavir
- mefloquine
- mepivacaine
- metoprolol
- midodrine
- nadolol
- nebivolol
- neostigmine
- phenytoin
- pindolol
- praziquantel
- propranolol
- quinidine (antiarrhythmic)
- ritonavir
- ropivacaine
- thalidomide
- theophylline
- ticagrelor
- timolol
- timolol ophthalmic
- verapamil
Caution Advised
- brivaracetam
- cannabidiol
- cenobamate
- clonazepam
- diazepam
- eslicarbazepine acetate
- fenfluramine
- gabapentin
- ganaxolone
- hydroxychloroquine
- levetiracetam
- magnesium citrate
- methsuximide
- oxcarbazepine
- perampanel
- phenobarbital
- polyethylene glycol
- polyethylene glycol/electrolytes
- pregabalin
- primidone
- rufinamide
- sodium phosphate (bowel prep)
- sodium picosulfate
- stiripentol
- sulfate bowel prep
- tiagabine
- tramadol
- valproic acid
- vigabatrin
- zonisamide
Adverse Reactions .
Serious Reactions
- cardiac arrest
- atrial arrhythmia
- ventricular arrhythmia
- myocardial ischemia
- MI
- sinoatrial block
- AV block
- bradycardia
- hypotension, severe
- HTN
- hypersensitivity rxn
- anaphylaxis
- respiratory arrest
- bronchoconstriction
- TIA
- seizures
- syncope
- hemorrhagic stroke
- ischemic stroke
Common Reactions
- dyspnea
- headache
- tachycardia
- arrhythmia
- flushing
- chest discomfort
- angina
- ST segment depression
- dizziness
- chest pain
- ventricular conduction disturbance
- nausea
- abdominal discomfort
- dysgeusia
- warmth sensation
- AV block, 1st degree
- hypotension
Safety/Monitoring .
Monitoring Parameters
ECG
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; possible risk of decr. fetal wt, ossification delays, skeletal variations, and embryo-fetal death based on animal data at up to 20x MRHD
Lactation
Clinical Summary
avoid breastfeeding x10h after each dose; no human data available to assess risk of infant harm, though possible drug excretion into milk; no human data available to assess effects on milk production
Pharmacology .
Metabolism: unknown; CYP450: none
Excretion: urine (57% unchanged); Half-life: 2h; Info: undergoes active tubular secretion
Subclass: Diagnostic Agents, Cardiovascular
Mechanism of Action
activates A2A adenosine receptors, producing coronary vasodilation and incr. blood flow
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: Astellas Pharma US, Inc.
DEA/FDA: Rx
Approximate Retail Price
from http://www.goodrx.com/lexiscan
intravenous solution:
- 0.08 mg/mL (1 syringe, 5 mL): $265.00
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