Select a medication above to begin.
sotalol
generic
Black Box Warnings .
Appropriate Use
to minimize induced arrhythmia risk, initiate and titrate dose in facility w/ cont. EKG until on stable maint. dose x3 days; calculate CrCl prior to dosing
Life-threatening Proarrhythmia
can cause life-threatening ventricular tachycardia assoc. w/ QT interval prolongation; do not start tx if baseline QTc >450 msec; if QTc interval prolongs to >500 msec, decr. dose, incr. dose interval, or D/C tx
Adult Dosing .
Dosage forms: TAB: 80 mg, 120 mg, 160 mg, 240 mg; TAB (AF): 80 mg, 120 mg, 160 mg; INJ: various
ventricular arrhythmias, life-threatening
- [IV loading dose]
- Dose: based on target PO dose and CrCl, see pkg insert; Info: may use to achieve faster steady-state drug exposure before start/incr. PO dose; initiate/titrate dose in hospital w/ cardiac monitor; start 1st PO dose after 4h
- [treatment dose]
- Dose: 80-160 mg PO q12h; Start: 80 mg PO q12h, may incr. by 40 mg/dose q3 days; Max: 640 mg/day PO; Alt: start 75 mg IV q12h, may incr. by 37.5 mg/dose q3 days to 150 mg IV q12h, max 600 mg/day IV; Info: initiate/titrate dose in hospital w/ cardiac monitor; taper dose over 1-2wk to D/C
atrial fibrillation/flutter
- [IV loading dose]
- Dose: based on target PO dose and CrCl, see pkg insert; Info: may use to achieve faster steady-state drug exposure before start/incr. PO dose; initiate/titrate dose in hospital w/ cardiac monitor; start 1st PO dose after 4h
- [treatment dose]
- Dose: 80-160 mg PO q12h; Start: 80 mg PO q12h, may incr. by 40 mg/dose q3 days; Max: 320 mg/day PO; Alt: start 75 mg IV q12h, may incr. by 37.5 mg/dose q3 days to 150 mg IV q12h, max 300 mg/day IV; Info: for pts w/ symptomatic atrial fibrillation/flutter, currently in normal sinus rhythm; initiate/titrate dose in hospital w/ cardiac monitor; taper dose over 1-2wk to D/C
essential tremor (off-label)
- [80 mg PO bid]
- Info: taper dose over 1-2wk to D/C
renal dosing
- [IV loading dose]
- renal impairment: dose adjustment based on target PO dose and CrCl, see pkg insert
- HD/PD: not defined
- [treatment dose]
- CrCl 30-59: give usual dose q24h; CrCl 10-29: give usual dose q36-48h; CrCl <10: individualize dose; Info: may incr. dose after at least 5 doses
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: TAB: 80 mg, 120 mg, 160 mg, 240 mg; TAB (AF): 80 mg, 120 mg, 160 mg; INJ: various
ventricular arrhythmias, life-threatening
- [PO route, <2 yo]
- Dose: based on wt and age-specific factor, see pkg insert; Info: initiate/titrate dose in hospital w/ cardiac monitor; taper dose over 1-2wk to D/C
- [PO route, 2 yo and older]
- Dose: 1.2-2.4 mg/kg/dose PO tid; Start: 1.2 mg/kg/dose PO tid, may incr. dose no more frequently than q36h; Max: 7.2 mg/kg/day; Info: initiate/titrate dose in hospital w/ cardiac monitor; taper dose over 1-2wk to D/C
- [IV route (off-label)]
- Dose: 1 mg/kg/dose IV x1, then 3-4.5 mg/kg/day IV; Info: initiate/titrate dose in hospital w/ cardiac monitor; switch to PO form when possible
atrial fibrillation/flutter
- [PO route, <2 yo]
- Dose: based on wt and age-specific factor, see pkg insert; Info: for pts w/ symptomatic atrial fibrillation/flutter, currently in normal sinus rhythm; initiate/titrate dose in hospital w/ cardiac monitor; taper dose over 1-2wk to D/C
- [PO route, 2 yo and older]
- Dose: 1.2-2.4 mg/kg/dose PO tid; Start: 1.2 mg/kg/dose PO tid, may incr. dose no more frequently than q36h; Max: 7.2 mg/kg/day; Info: for pts w/ symptomatic atrial fibrillation/flutter, currently in normal sinus rhythm; initiate/titrate dose in hospital w/ cardiac monitor; taper dose over 1-2wk to D/C
- [IV route (off-label)]
- Dose: 1 mg/kg/dose IV x1, then 3-4.5 mg/kg/day IV; Info: initiate/titrate dose in hospital w/ cardiac monitor; switch to PO form when possible
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: not defined
hepatic dosing
- [no adjustment]