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propylthiouracil
generic
Black Box Warnings .
Appropriate Use
reserve for pts intolerant to methimazole in whom radioactive iodine tx or surgery are not appropriate
Hepatotoxicity
severe hepatic injury and acute hepatic failure, incl. fatal, reported; some cases required liver transplant
Antithyroid Drug Use in 1st Trimester Pregnancy
propylthiouracil may be tx of choice during or just prior to 1st trimester pregnancy
Adult Dosing .
Dosage forms: TAB: 50 mg
hyperthyroidism
- [100-150 mg/day PO divided q8h]
- Start: 300-400 mg/day PO divided q8h; Info: some pts may require 600-900 mg/day initially; adjust dose based on TFTs
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: TAB: 50 mg
hyperthyroidism
- [neonates (off-label)]
- Start: 5-10 mg/kg/day PO divided q8h; Info: adjust dose based on TFTs; maint. dose usually 1/3-2/3 of start dose
- [children <6 yo (off-label)]
- Start: 5-7 mg/kg/day PO divided q8h; Info: adjust dose based on TFTs; maint. dose usually 1/3-2/3 of start dose
- [6-10 yo]
- Start: 50-150 mg/day PO divided q8h; Alt: start 5-7 mg/kg/day PO divided q8h; Info: adjust dose based on TFTs; maint. dose usually 1/3-2/3 of start dose
- [>10 yo]
- Start: 150-300 mg/day PO divided q8h; Alt: start 5-7 mg/kg/day PO divided q8h; Info: adjust dose based on TFTs; maint. dose usually 1/3-2/3 of start dose
renal dosing
- [see below]
- renal impairment: not defined; Info: consider dose adjustment if renal failure
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised