Select a medication above to begin.
hydroxyurea
generic
Adult Dosing .
Dosage forms: CAP: 500 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, concomitant meds to mitigate toxicity, and dosing incl. toxicity-related dose adjustments; use lower of IBW or ABW for dose calculations
CML, refractory
- [individualize dose PO qd]
- Start: 15 mg/kg/dose PO qd
squamous cell head/neck CA, XRT adjunct
- [500-1000 mg PO q12h x11 doses per cycle]
- Start: approx. 14h prior to initiation of XRT each cycle
sickle cell dz (off-label)
- [15-35 mg/kg/dose PO qd]
- Start: 15 mg/kg/dose PO qd; Max: 35 mg/kg/day; Info: titrate by 5 mg/kg/day q12wk
polycythemia vera (off-label)
- [500-1500 mg PO qd]
- Info: titrate to control Hct and platelet count
thrombocythemia, essential (off-label)
- [15 mg/kg/dose PO qd]
- Info: titrate to control platelets and maintain WBC count
renal dosing
- [adjust dose amount]
- CrCl <60: decr. usual dose by 50%
- HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: CAP: 500 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, concomitant meds to mitigate toxicity, and dosing incl. toxicity-related dose adjustments; use lower of IBW or ABW for dose calculations
sickle cell dz
- [2 yo and older]
- Dose: 20-35 mg/kg/dose PO qd; Start: 20 mg/kg/dose PO qd; Max: 35 mg/kg/day; Info: titrate by 5 mg/kg/day q8wk
renal dosing
- [adjust dose amount]
- CrCl <60: decr. usual dose by 50%
- HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement
hepatic dosing
- [not defined]