Select a medication above to begin.
hydralazine
generic
Adult Dosing .
Dosage forms: TAB: 10 mg, 25 mg, 50 mg, 100 mg; INJ: 20 mg per mL
HTN, mod-severe
- [10-50 mg PO qid]
- Start: 10 mg PO qid x2-4 days, then may incr. to 25 mg PO qid x1wk, then may incr. to 50 mg PO qid; Max: 300 mg/day PO; Alt: 10-20 mg IM/IV q4-6h prn, switch to PO ASAP; Info: adjust to lowest effective dose for maintenance
heart failure w/ reduced ejection fraction (off-label)
- [100 mg PO tid]
- Start: 25 mg PO tid, may incr. dose q2wk; Max: 300 mg/day; Info: give w/ isosorbide dinitrate
hypertensive crisis (off-label)
- [10-20 mg IM/IV q2-4h]
- Info: switch to PO ASAP
hypertensive emergency, pregnancy-assoc. (off-label)
- [5-10 mg IV q20-40min prn]
- Start: 5 mg IM/IV x1; Max: 20 mg/total dose; Alt: 0.5-10 mg/h IV
renal dosing
- [PO route]
- renal impairment: no adjustment
- HD/PD: not defined
- [IV route]
- renal impairment: not defined; Info: consider decr. usual dose if marked impairment
- HD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: TAB: 10 mg, 25 mg, 50 mg, 100 mg; INJ: 20 mg per mL
HTN, acute severe (off-label)
- [PO route]
- Dose: 0.25 mg/kg/dose PO q6-8h; Max: 25 mg/dose; Info: for pts w/ non-life-threatening sx
- [IV route]
- Dose: 0.1-0.2 mg/kg/dose IM/IV q4-6h; Max: 0.4 mg/kg/dose up to 20 mg/dose; Info: for pts w/ life-threatening sx; switch to PO ASAP
HTN, chronic (off-label)
- [1-23 mo]
- Dose: 0.75-5 mg/kg/day PO divided q6-12h; Start: 0.75-1 mg/kg/day PO divided q6-12h, incr. slowly over 3-4wk prn; Max: 5 mg/kg/day
- [2-12 yo]
- Dose: 0.75-5 mg/kg/day PO divided q6-12h; Start: 0.75-1 mg/kg/day PO divided q6-12h, incr. slowly over 3-4wk prn; Max: 7.5 mg/kg/day or 200 mg/day
- [13 yo and older]
- Dose: 10-50 mg PO qid; Start: 10 mg PO qid x2-4 days, then 25 mg PO qid x1wk; Max: 300 mg/day PO; Alt: 10-40 mg IM/IV q4-6h, switch to PO ASAP
renal dosing
- [adjust dose frequency]
- CrCl 10-50: give usual dose q8h; CrCl <10: give usual dose q8-16h
- HD: give usual dose q8-16h; no supplement after dialysis; PD: give usual dose q8-16h; no supplement
hepatic dosing
- [not defined]