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vecuronium
generic
Black Box Warnings .
Appropriate Use
admin. by adequately trained individuals familiar w/ actions, characteristics, and hazards
Adult Dosing .
Dosage forms: INJ
neuromuscular blockade induction
- [80-100 mcg/kg/dose IV x1]
- Info: decr. dose to 60-85 mcg/kg/dose if under isoflurane or enflurane anesthesia; if following succinylcholine-assisted intubation, decr. dose to 40-60 mcg/kg under inhalation anesthesia, 50-60 mcg/kg under balanced anesthesia; onset 2.5-3min, 25% recovery 25-40min (intermediate-acting)
neuromuscular blockade maintenance
- [intermittent IV]
- Dose: 10-15 mcg/kg/dose IV q12-15min prn; Info: give 1st maint. dose w/in 25-40min of induction dose
- [continuous IV]
- Dose: 0.8-1.2 mcg/kg/min IV; Start: 1 mcg/kg/min IV after induction dose; Info: start infusion 45-60min after induction dose and decr. rate 25-60% if under isoflurane or enflurane anesthesia
renal dosing
- [see below]
- renal impairment: no adjustment; Info: consider decr. usual dose if anephric
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ
neuromuscular blockade induction
- [7 wk old-11 mo]
- Dose: 80-100 mcg/kg/dose IV x1; Info: onset 2.5-3min, 25% recovery 37-60min (intermediate-acting)
- [1 yo and older]
- see Adult Dosing
neuromuscular blockade maintenance
- [7 wk old-11 mo]
- Dose: 50-100 mcg/kg/dose IV q1h prn
- [1 yo and older]
- see Adult Dosing
renal dosing
- [see below]
- renal impairment: no adjustment; Info: consider decr. usual dose if anephric
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised